Ibuprofen-induced inhibition of cyclooxygenase isoform gene expression and regression of rat mammary carcinomas

Fredika M. Robertson; Michelle L. Parrett; Farahnaz S. Joarder; Mary Ross; Hussein M. Abou-Issa; Galal Alshafie; Randall E. Harris

doi:10.1016/S0304-3835(97)00387-X

Ibuprofen-induced inhibition of cyclooxygenase isoform gene expression and regression of rat mammary carcinomas

Fredika M. Robertson, Michelle L. Parrett, Farahnaz S. Joarder, Mary Ross, Hussein M. Abou-Issa, Galal Alshafie, Randall E. Harris

Research output: Contribution to journal › Article › peer-review

82 Scopus citations

Abstract

A single dose of 75 mg/kg 7,12 dimethylbenz[a]anthracene was administered to 50-day-old virgin female Sprague-Dawley rats and 100 days later, animals were randomized and provided with Teklad rodent chow mixed with a dose of 25 mg/rat/day ibuprofen for 35 days. Ibuprofen treatment reduced tumor volume (P < 0.05) and significantly inhibited gene expression of both cyclooxygenase-1 and cyclooxygenase-2 (P < 0.02). These results indicate that ibuprofen induced significant regression of established mammary carcinomas which was associated with inhibition of expression of isoforms of the gene responsible for prostaglandin production.

Original language	English (US)
Pages (from-to)	165-175
Number of pages	11
Journal	Cancer Letters
Volume	122
Issue number	1-2
DOIs	https://doi.org/10.1016/S0304-3835(97)00387-X
State	Published - Jan 9 1998
Externally published	Yes

Keywords

COX
Ibuprofen
Mammary carcinoma
NSAIDs
Prostaglandin G/H synthase

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/S0304-3835(97)00387-X

Cite this

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title = "Ibuprofen-induced inhibition of cyclooxygenase isoform gene expression and regression of rat mammary carcinomas",

abstract = "A single dose of 75 mg/kg 7,12 dimethylbenz[a]anthracene was administered to 50-day-old virgin female Sprague-Dawley rats and 100 days later, animals were randomized and provided with Teklad rodent chow mixed with a dose of 25 mg/rat/day ibuprofen for 35 days. Ibuprofen treatment reduced tumor volume (P < 0.05) and significantly inhibited gene expression of both cyclooxygenase-1 and cyclooxygenase-2 (P < 0.02). These results indicate that ibuprofen induced significant regression of established mammary carcinomas which was associated with inhibition of expression of isoforms of the gene responsible for prostaglandin production.",

keywords = "COX, Ibuprofen, Mammary carcinoma, NSAIDs, Prostaglandin G/H synthase",

author = "Robertson, {Fredika M.} and Parrett, {Michelle L.} and Joarder, {Farahnaz S.} and Mary Ross and Abou-Issa, {Hussein M.} and Galal Alshafie and Harris, {Randall E.}",

note = "Funding Information: This work was supported in part by the Charlotte Geyer Foundation, NIH NCI R21 CA-66193, NIH NCI P30 CA-16058 and a grant to the Center for Molecular and Environmental Health from the Ohio Environmental Protection Agency. ",

year = "1998",

month = jan,

day = "9",

doi = "10.1016/S0304-3835(97)00387-X",

language = "English (US)",

volume = "122",

pages = "165--175",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "1-2",

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TY - JOUR

T1 - Ibuprofen-induced inhibition of cyclooxygenase isoform gene expression and regression of rat mammary carcinomas

AU - Robertson, Fredika M.

AU - Parrett, Michelle L.

AU - Joarder, Farahnaz S.

AU - Ross, Mary

AU - Abou-Issa, Hussein M.

AU - Alshafie, Galal

AU - Harris, Randall E.

N1 - Funding Information: This work was supported in part by the Charlotte Geyer Foundation, NIH NCI R21 CA-66193, NIH NCI P30 CA-16058 and a grant to the Center for Molecular and Environmental Health from the Ohio Environmental Protection Agency.

PY - 1998/1/9

Y1 - 1998/1/9

N2 - A single dose of 75 mg/kg 7,12 dimethylbenz[a]anthracene was administered to 50-day-old virgin female Sprague-Dawley rats and 100 days later, animals were randomized and provided with Teklad rodent chow mixed with a dose of 25 mg/rat/day ibuprofen for 35 days. Ibuprofen treatment reduced tumor volume (P < 0.05) and significantly inhibited gene expression of both cyclooxygenase-1 and cyclooxygenase-2 (P < 0.02). These results indicate that ibuprofen induced significant regression of established mammary carcinomas which was associated with inhibition of expression of isoforms of the gene responsible for prostaglandin production.

AB - A single dose of 75 mg/kg 7,12 dimethylbenz[a]anthracene was administered to 50-day-old virgin female Sprague-Dawley rats and 100 days later, animals were randomized and provided with Teklad rodent chow mixed with a dose of 25 mg/rat/day ibuprofen for 35 days. Ibuprofen treatment reduced tumor volume (P < 0.05) and significantly inhibited gene expression of both cyclooxygenase-1 and cyclooxygenase-2 (P < 0.02). These results indicate that ibuprofen induced significant regression of established mammary carcinomas which was associated with inhibition of expression of isoforms of the gene responsible for prostaglandin production.

KW - COX

KW - Ibuprofen

KW - Mammary carcinoma

KW - NSAIDs

KW - Prostaglandin G/H synthase

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U2 - 10.1016/S0304-3835(97)00387-X

DO - 10.1016/S0304-3835(97)00387-X

M3 - Article

C2 - 9464506

AN - SCOPUS:0032498246

SN - 0304-3835

VL - 122

SP - 165

EP - 175

JO - Cancer Letters

JF - Cancer Letters

IS - 1-2

ER -

Ibuprofen-induced inhibition of cyclooxygenase isoform gene expression and regression of rat mammary carcinomas

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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