Ibotenic acid lesions of prefrontal cortex do not prevent expression of behavioral sensitization to amphetamine

Yong Li, Marina Wolf

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

We have shown previously that ibotenic acid lesions of the prefrontal cortex, performed prior to repeated amphetamine administration, do not affect sensitization of stereotyped behaviors but do prevent sensitization of post-stereotypy locomotor hyperactivity [Wolf et al., Neuroscience, 69 (1995) 417-439]. This could reflect an effect of the lesion on either development or expression of locomotor sensitization. To test the latter possibility, rats were treated with repeated amphetamine injections and tested to establish behavioral sensitization. Then, half received ibotenic acid lesions of prefrontal cortex and half received sham lesions. A second amphetamine challenge, 7 days later, demonstrated that the lesion failed to prevent expression of sensitization. Together with previous results, this suggests that intrinsic neurons of prefrontal cortex, most likely those sending excitatory amino acid-containing projections to the ventral tegmental area, are required for the development but not the expression of behavioral sensitization to amphetamine.

Original languageEnglish (US)
Pages (from-to)285-289
Number of pages5
JournalBehavioural Brain Research
Volume84
Issue number1-2
DOIs
StatePublished - Mar 1 1997
Externally publishedYes

Fingerprint

Ibotenic Acid
Amphetamine
Prefrontal Cortex
Stereotyped Behavior
Ventral Tegmental Area
Excitatory Amino Acids
Neurosciences
Neurons
Injections

Keywords

  • amphetamine
  • behavioral sensitization
  • excitatory amino acids
  • ibotenic acid
  • prefrontal cortex
  • ventral tegmental area

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Ibotenic acid lesions of prefrontal cortex do not prevent expression of behavioral sensitization to amphetamine. / Li, Yong; Wolf, Marina.

In: Behavioural Brain Research, Vol. 84, No. 1-2, 01.03.1997, p. 285-289.

Research output: Contribution to journalArticle

@article{b74c0444a6b74c758b1b6180f2bc4543,
title = "Ibotenic acid lesions of prefrontal cortex do not prevent expression of behavioral sensitization to amphetamine",
abstract = "We have shown previously that ibotenic acid lesions of the prefrontal cortex, performed prior to repeated amphetamine administration, do not affect sensitization of stereotyped behaviors but do prevent sensitization of post-stereotypy locomotor hyperactivity [Wolf et al., Neuroscience, 69 (1995) 417-439]. This could reflect an effect of the lesion on either development or expression of locomotor sensitization. To test the latter possibility, rats were treated with repeated amphetamine injections and tested to establish behavioral sensitization. Then, half received ibotenic acid lesions of prefrontal cortex and half received sham lesions. A second amphetamine challenge, 7 days later, demonstrated that the lesion failed to prevent expression of sensitization. Together with previous results, this suggests that intrinsic neurons of prefrontal cortex, most likely those sending excitatory amino acid-containing projections to the ventral tegmental area, are required for the development but not the expression of behavioral sensitization to amphetamine.",
keywords = "amphetamine, behavioral sensitization, excitatory amino acids, ibotenic acid, prefrontal cortex, ventral tegmental area",
author = "Yong Li and Marina Wolf",
year = "1997",
month = "3",
day = "1",
doi = "10.1016/S0166-4328(96)00158-1",
language = "English (US)",
volume = "84",
pages = "285--289",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Ibotenic acid lesions of prefrontal cortex do not prevent expression of behavioral sensitization to amphetamine

AU - Li, Yong

AU - Wolf, Marina

PY - 1997/3/1

Y1 - 1997/3/1

N2 - We have shown previously that ibotenic acid lesions of the prefrontal cortex, performed prior to repeated amphetamine administration, do not affect sensitization of stereotyped behaviors but do prevent sensitization of post-stereotypy locomotor hyperactivity [Wolf et al., Neuroscience, 69 (1995) 417-439]. This could reflect an effect of the lesion on either development or expression of locomotor sensitization. To test the latter possibility, rats were treated with repeated amphetamine injections and tested to establish behavioral sensitization. Then, half received ibotenic acid lesions of prefrontal cortex and half received sham lesions. A second amphetamine challenge, 7 days later, demonstrated that the lesion failed to prevent expression of sensitization. Together with previous results, this suggests that intrinsic neurons of prefrontal cortex, most likely those sending excitatory amino acid-containing projections to the ventral tegmental area, are required for the development but not the expression of behavioral sensitization to amphetamine.

AB - We have shown previously that ibotenic acid lesions of the prefrontal cortex, performed prior to repeated amphetamine administration, do not affect sensitization of stereotyped behaviors but do prevent sensitization of post-stereotypy locomotor hyperactivity [Wolf et al., Neuroscience, 69 (1995) 417-439]. This could reflect an effect of the lesion on either development or expression of locomotor sensitization. To test the latter possibility, rats were treated with repeated amphetamine injections and tested to establish behavioral sensitization. Then, half received ibotenic acid lesions of prefrontal cortex and half received sham lesions. A second amphetamine challenge, 7 days later, demonstrated that the lesion failed to prevent expression of sensitization. Together with previous results, this suggests that intrinsic neurons of prefrontal cortex, most likely those sending excitatory amino acid-containing projections to the ventral tegmental area, are required for the development but not the expression of behavioral sensitization to amphetamine.

KW - amphetamine

KW - behavioral sensitization

KW - excitatory amino acids

KW - ibotenic acid

KW - prefrontal cortex

KW - ventral tegmental area

UR - http://www.scopus.com/inward/record.url?scp=0031048394&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031048394&partnerID=8YFLogxK

U2 - 10.1016/S0166-4328(96)00158-1

DO - 10.1016/S0166-4328(96)00158-1

M3 - Article

C2 - 9079793

AN - SCOPUS:0031048394

VL - 84

SP - 285

EP - 289

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

IS - 1-2

ER -