Ibotenic acid lesions of prefrontal cortex do not prevent expression of behavioral sensitization to amphetamine

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Abstract

We have shown previously that ibotenic acid lesions of the prefrontal cortex, performed prior to repeated amphetamine administration, do not affect sensitization of stereotyped behaviors but do prevent sensitization of post-stereotypy locomotor hyperactivity [Wolf et al., Neuroscience, 69 (1995) 417-439]. This could reflect an effect of the lesion on either development or expression of locomotor sensitization. To test the latter possibility, rats were treated with repeated amphetamine injections and tested to establish behavioral sensitization. Then, half received ibotenic acid lesions of prefrontal cortex and half received sham lesions. A second amphetamine challenge, 7 days later, demonstrated that the lesion failed to prevent expression of sensitization. Together with previous results, this suggests that intrinsic neurons of prefrontal cortex, most likely those sending excitatory amino acid-containing projections to the ventral tegmental area, are required for the development but not the expression of behavioral sensitization to amphetamine.

Original languageEnglish (US)
Pages (from-to)285-289
Number of pages5
JournalBehavioural Brain Research
Volume84
Issue number1-2
DOIs
StatePublished - Mar 1 1997

Keywords

  • amphetamine
  • behavioral sensitization
  • excitatory amino acids
  • ibotenic acid
  • prefrontal cortex
  • ventral tegmental area

ASJC Scopus subject areas

  • Behavioral Neuroscience

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