Iatrogenic choroidal neovascularization associated with subretinal gene therapy surgery

Kenneth W. Price; Mark E. Pennesi; Andreas K. Lauer; Steven T. Bailey

doi:10.1016/j.ajoc.2022.101677

Iatrogenic choroidal neovascularization associated with subretinal gene therapy surgery

Kenneth W. Price, Mark E. Pennesi, Andreas K. Lauer, Steven T. Bailey

Ophthalmology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Purpose: To report a case of iatrogenic choroidal neovascularization (CNV) developing one month after subretinal gene therapy surgery. Observations: A 16-year-old male with biallelic RPE65 mutation associated retinal dystrophy was treated with subretinal voretigene neparvovec in the left eye. During initiation of a balanced salt solution pre-bleb, a faint and transient subretinal hemorrhage was observed at the retinotomy site. One month post-operatively, multi-modal imaging detected a CNV and a break in Bruch's membrane at the retinotomy site. The asymptomatic CNV was observed without treatment and resolved spontaneously. Conclusions & importance: As subretinal gene therapy surgery becomes more common, clinicians should monitor for possible trauma induced CNV associated with retinotomy formation and subretinal injection.

Original language	English (US)
Article number	101677
Journal	American Journal of Ophthalmology Case Reports
Volume	27
DOIs	https://doi.org/10.1016/j.ajoc.2022.101677
State	Published - Sep 2022

Keywords

Macular surgery
Subretinal gene therapy
Traumatic choroidal neovascularization

ASJC Scopus subject areas

Ophthalmology

Access to Document

10.1016/j.ajoc.2022.101677

Cite this

@article{51da2a93a90a4061bb1aa31f009bd1b8,

title = "Iatrogenic choroidal neovascularization associated with subretinal gene therapy surgery",

abstract = "Purpose: To report a case of iatrogenic choroidal neovascularization (CNV) developing one month after subretinal gene therapy surgery. Observations: A 16-year-old male with biallelic RPE65 mutation associated retinal dystrophy was treated with subretinal voretigene neparvovec in the left eye. During initiation of a balanced salt solution pre-bleb, a faint and transient subretinal hemorrhage was observed at the retinotomy site. One month post-operatively, multi-modal imaging detected a CNV and a break in Bruch's membrane at the retinotomy site. The asymptomatic CNV was observed without treatment and resolved spontaneously. Conclusions & importance: As subretinal gene therapy surgery becomes more common, clinicians should monitor for possible trauma induced CNV associated with retinotomy formation and subretinal injection.",

keywords = "Macular surgery, Subretinal gene therapy, Traumatic choroidal neovascularization",

author = "Price, {Kenneth W.} and Pennesi, {Mark E.} and Lauer, {Andreas K.} and Bailey, {Steven T.}",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2022",

month = sep,

doi = "10.1016/j.ajoc.2022.101677",

language = "English (US)",

volume = "27",

journal = "American Journal of Ophthalmology Case Reports",

issn = "2451-9936",

publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Iatrogenic choroidal neovascularization associated with subretinal gene therapy surgery

AU - Price, Kenneth W.

AU - Pennesi, Mark E.

AU - Lauer, Andreas K.

AU - Bailey, Steven T.

PY - 2022/9

Y1 - 2022/9

N2 - Purpose: To report a case of iatrogenic choroidal neovascularization (CNV) developing one month after subretinal gene therapy surgery. Observations: A 16-year-old male with biallelic RPE65 mutation associated retinal dystrophy was treated with subretinal voretigene neparvovec in the left eye. During initiation of a balanced salt solution pre-bleb, a faint and transient subretinal hemorrhage was observed at the retinotomy site. One month post-operatively, multi-modal imaging detected a CNV and a break in Bruch's membrane at the retinotomy site. The asymptomatic CNV was observed without treatment and resolved spontaneously. Conclusions & importance: As subretinal gene therapy surgery becomes more common, clinicians should monitor for possible trauma induced CNV associated with retinotomy formation and subretinal injection.

AB - Purpose: To report a case of iatrogenic choroidal neovascularization (CNV) developing one month after subretinal gene therapy surgery. Observations: A 16-year-old male with biallelic RPE65 mutation associated retinal dystrophy was treated with subretinal voretigene neparvovec in the left eye. During initiation of a balanced salt solution pre-bleb, a faint and transient subretinal hemorrhage was observed at the retinotomy site. One month post-operatively, multi-modal imaging detected a CNV and a break in Bruch's membrane at the retinotomy site. The asymptomatic CNV was observed without treatment and resolved spontaneously. Conclusions & importance: As subretinal gene therapy surgery becomes more common, clinicians should monitor for possible trauma induced CNV associated with retinotomy formation and subretinal injection.

KW - Macular surgery

KW - Subretinal gene therapy

KW - Traumatic choroidal neovascularization

UR - http://www.scopus.com/inward/record.url?scp=85135876105&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85135876105&partnerID=8YFLogxK

U2 - 10.1016/j.ajoc.2022.101677

DO - 10.1016/j.ajoc.2022.101677

M3 - Article

AN - SCOPUS:85135876105

SN - 2451-9936

VL - 27

JO - American Journal of Ophthalmology Case Reports

JF - American Journal of Ophthalmology Case Reports

M1 - 101677

ER -

Iatrogenic choroidal neovascularization associated with subretinal gene therapy surgery

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this