Hypotonic and isotonic aerosols increase bronchial reactivity in basenji-greyhound dogs

Molly Osborne, T. W. Evans, C. P. Sommerhoff, K. F. Chung, C. A. Hirshman, H. A. Boushey, J. A. Nadel

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Because basenji-greyhound dogs have greater bronchial reactivity to a range of inhaled stimuli than mongrel dogs do, and because bronchial hyperreactivity to nonspecific stimuli is characteristic of asthma, we asked whether basenji-greyhound dogs have greater bronchial reactivity to hypotonic and isotonic aerosols than mongrel dogs do. We assessed bronchial reactivity by measuring both the total pulmonary resistance and the bronchial response to an acetylcholine aerosol, before and after delivery of hypotonic and isotonic aerosols. Bronchial reactivity as measured by a change in total pulmonary resistance increased 9-fold after delivery of hypotonic and 5-fold after delivery of isotonic aerosols in 5 anesthetized basenji-greyhound dogs, but not in 3 similarly challenged mongrel dogs (p <0.01). Bronchial reactivity as measured by an increased bronchial response to acetylcholine aerosol increased 3-fold in basenji-greyhound dogs but not in mongrel dogs. Thus, hypotonic and isotonic aerosols increase bronchial reactivity in basenji-greyhound dogs. We also asked whether vagal or nonvagal pathways are involved in the increase in total pulmonary resistance induced by a hypotonic aerosol. Both vagal and nonvagal pathways appear to be involved, since blockade of the vagal pathway by intravenously administered atropine only partially inhibited the bronchoconstriction induced by a hypotonic aerosol (54%). Disodium cromoglycate, which inhibits vagal and nonvagal pathways, partially inhibited the bronchoconstriction (57%), but even in combination with atropine, did not completely inhibit it (68%). Our observations in basenji-greyhound dogs are similar to results in asthmatic subjects, suggesting that basenji-greyhound dogs are useful experimental animals in which to study the mechanisms by which hypotonic and isotonic aerosols increase bronchial reactivity.

Original languageEnglish (US)
Pages (from-to)345-349
Number of pages5
JournalAmerican Review of Respiratory Disease
Volume135
Issue number2
StatePublished - 1987
Externally publishedYes

Fingerprint

Aerosols
Dogs
Bronchoconstriction
Atropine
Lung
Acetylcholine
Bronchial Hyperreactivity
Cromolyn Sodium
Asthma

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Osborne, M., Evans, T. W., Sommerhoff, C. P., Chung, K. F., Hirshman, C. A., Boushey, H. A., & Nadel, J. A. (1987). Hypotonic and isotonic aerosols increase bronchial reactivity in basenji-greyhound dogs. American Review of Respiratory Disease, 135(2), 345-349.

Hypotonic and isotonic aerosols increase bronchial reactivity in basenji-greyhound dogs. / Osborne, Molly; Evans, T. W.; Sommerhoff, C. P.; Chung, K. F.; Hirshman, C. A.; Boushey, H. A.; Nadel, J. A.

In: American Review of Respiratory Disease, Vol. 135, No. 2, 1987, p. 345-349.

Research output: Contribution to journalArticle

Osborne, M, Evans, TW, Sommerhoff, CP, Chung, KF, Hirshman, CA, Boushey, HA & Nadel, JA 1987, 'Hypotonic and isotonic aerosols increase bronchial reactivity in basenji-greyhound dogs', American Review of Respiratory Disease, vol. 135, no. 2, pp. 345-349.
Osborne M, Evans TW, Sommerhoff CP, Chung KF, Hirshman CA, Boushey HA et al. Hypotonic and isotonic aerosols increase bronchial reactivity in basenji-greyhound dogs. American Review of Respiratory Disease. 1987;135(2):345-349.
Osborne, Molly ; Evans, T. W. ; Sommerhoff, C. P. ; Chung, K. F. ; Hirshman, C. A. ; Boushey, H. A. ; Nadel, J. A. / Hypotonic and isotonic aerosols increase bronchial reactivity in basenji-greyhound dogs. In: American Review of Respiratory Disease. 1987 ; Vol. 135, No. 2. pp. 345-349.
@article{6d9e984de5e24a7982dbf19f03b9ca1b,
title = "Hypotonic and isotonic aerosols increase bronchial reactivity in basenji-greyhound dogs",
abstract = "Because basenji-greyhound dogs have greater bronchial reactivity to a range of inhaled stimuli than mongrel dogs do, and because bronchial hyperreactivity to nonspecific stimuli is characteristic of asthma, we asked whether basenji-greyhound dogs have greater bronchial reactivity to hypotonic and isotonic aerosols than mongrel dogs do. We assessed bronchial reactivity by measuring both the total pulmonary resistance and the bronchial response to an acetylcholine aerosol, before and after delivery of hypotonic and isotonic aerosols. Bronchial reactivity as measured by a change in total pulmonary resistance increased 9-fold after delivery of hypotonic and 5-fold after delivery of isotonic aerosols in 5 anesthetized basenji-greyhound dogs, but not in 3 similarly challenged mongrel dogs (p <0.01). Bronchial reactivity as measured by an increased bronchial response to acetylcholine aerosol increased 3-fold in basenji-greyhound dogs but not in mongrel dogs. Thus, hypotonic and isotonic aerosols increase bronchial reactivity in basenji-greyhound dogs. We also asked whether vagal or nonvagal pathways are involved in the increase in total pulmonary resistance induced by a hypotonic aerosol. Both vagal and nonvagal pathways appear to be involved, since blockade of the vagal pathway by intravenously administered atropine only partially inhibited the bronchoconstriction induced by a hypotonic aerosol (54{\%}). Disodium cromoglycate, which inhibits vagal and nonvagal pathways, partially inhibited the bronchoconstriction (57{\%}), but even in combination with atropine, did not completely inhibit it (68{\%}). Our observations in basenji-greyhound dogs are similar to results in asthmatic subjects, suggesting that basenji-greyhound dogs are useful experimental animals in which to study the mechanisms by which hypotonic and isotonic aerosols increase bronchial reactivity.",
author = "Molly Osborne and Evans, {T. W.} and Sommerhoff, {C. P.} and Chung, {K. F.} and Hirshman, {C. A.} and Boushey, {H. A.} and Nadel, {J. A.}",
year = "1987",
language = "English (US)",
volume = "135",
pages = "345--349",
journal = "American Journal of Respiratory and Critical Care Medicine",
issn = "1073-449X",
publisher = "American Thoracic Society",
number = "2",

}

TY - JOUR

T1 - Hypotonic and isotonic aerosols increase bronchial reactivity in basenji-greyhound dogs

AU - Osborne, Molly

AU - Evans, T. W.

AU - Sommerhoff, C. P.

AU - Chung, K. F.

AU - Hirshman, C. A.

AU - Boushey, H. A.

AU - Nadel, J. A.

PY - 1987

Y1 - 1987

N2 - Because basenji-greyhound dogs have greater bronchial reactivity to a range of inhaled stimuli than mongrel dogs do, and because bronchial hyperreactivity to nonspecific stimuli is characteristic of asthma, we asked whether basenji-greyhound dogs have greater bronchial reactivity to hypotonic and isotonic aerosols than mongrel dogs do. We assessed bronchial reactivity by measuring both the total pulmonary resistance and the bronchial response to an acetylcholine aerosol, before and after delivery of hypotonic and isotonic aerosols. Bronchial reactivity as measured by a change in total pulmonary resistance increased 9-fold after delivery of hypotonic and 5-fold after delivery of isotonic aerosols in 5 anesthetized basenji-greyhound dogs, but not in 3 similarly challenged mongrel dogs (p <0.01). Bronchial reactivity as measured by an increased bronchial response to acetylcholine aerosol increased 3-fold in basenji-greyhound dogs but not in mongrel dogs. Thus, hypotonic and isotonic aerosols increase bronchial reactivity in basenji-greyhound dogs. We also asked whether vagal or nonvagal pathways are involved in the increase in total pulmonary resistance induced by a hypotonic aerosol. Both vagal and nonvagal pathways appear to be involved, since blockade of the vagal pathway by intravenously administered atropine only partially inhibited the bronchoconstriction induced by a hypotonic aerosol (54%). Disodium cromoglycate, which inhibits vagal and nonvagal pathways, partially inhibited the bronchoconstriction (57%), but even in combination with atropine, did not completely inhibit it (68%). Our observations in basenji-greyhound dogs are similar to results in asthmatic subjects, suggesting that basenji-greyhound dogs are useful experimental animals in which to study the mechanisms by which hypotonic and isotonic aerosols increase bronchial reactivity.

AB - Because basenji-greyhound dogs have greater bronchial reactivity to a range of inhaled stimuli than mongrel dogs do, and because bronchial hyperreactivity to nonspecific stimuli is characteristic of asthma, we asked whether basenji-greyhound dogs have greater bronchial reactivity to hypotonic and isotonic aerosols than mongrel dogs do. We assessed bronchial reactivity by measuring both the total pulmonary resistance and the bronchial response to an acetylcholine aerosol, before and after delivery of hypotonic and isotonic aerosols. Bronchial reactivity as measured by a change in total pulmonary resistance increased 9-fold after delivery of hypotonic and 5-fold after delivery of isotonic aerosols in 5 anesthetized basenji-greyhound dogs, but not in 3 similarly challenged mongrel dogs (p <0.01). Bronchial reactivity as measured by an increased bronchial response to acetylcholine aerosol increased 3-fold in basenji-greyhound dogs but not in mongrel dogs. Thus, hypotonic and isotonic aerosols increase bronchial reactivity in basenji-greyhound dogs. We also asked whether vagal or nonvagal pathways are involved in the increase in total pulmonary resistance induced by a hypotonic aerosol. Both vagal and nonvagal pathways appear to be involved, since blockade of the vagal pathway by intravenously administered atropine only partially inhibited the bronchoconstriction induced by a hypotonic aerosol (54%). Disodium cromoglycate, which inhibits vagal and nonvagal pathways, partially inhibited the bronchoconstriction (57%), but even in combination with atropine, did not completely inhibit it (68%). Our observations in basenji-greyhound dogs are similar to results in asthmatic subjects, suggesting that basenji-greyhound dogs are useful experimental animals in which to study the mechanisms by which hypotonic and isotonic aerosols increase bronchial reactivity.

UR - http://www.scopus.com/inward/record.url?scp=0023116504&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023116504&partnerID=8YFLogxK

M3 - Article

VL - 135

SP - 345

EP - 349

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

SN - 1073-449X

IS - 2

ER -