Abstract
The locomotor activity of male mice (Mus musculus) of 13 CXB (BALB/cBy x C57BL/6J) recombinant inbred (RI) strains and their progenitor strains was monitored for 4 to 6 weeks by infrared photoelectric beams under constant dark. The circadian period (τ) of locomotor activity was calculated and used in quantitative trait locus (QTL) analysis of strains' means. Results were compared with potential QTL found in a previous study of the BXD RI series. The mean τ of 13 CXB RI mouse strains (three to six animals per strain) in constant dark had a unimodal distribution suggesting polygenic inheritance. A number of potential QTL were found for this trait. There were two associations at p < .001, H23 on chromosome 3 and Pmv16 on chromosome 16. A region of chromosome 1 was associated with τ in both CXB and BXD RI series. There was also a conjunction with a locus determined from QTL analysis of the previously reported τ of wheel running activity in seven CXB RI strains (Schwartz and Zimmerman, 1990).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 505-511 |
| Number of pages | 7 |
| Journal | Behavior genetics |
| Volume | 26 |
| Issue number | 5 |
| DOIs | |
| State | Published - Sep 1996 |
Keywords
- Inbred mouse
- circadian rhythms
- genetics
- locomotor activity
- quantitative trait loci
ASJC Scopus subject areas
- Ecology, Evolution, Behavior and Systematics
- Genetics
- Genetics(clinical)