Hypothermic cerebral reperfusion and recovery from ischemia

W. A. Baldwin, Jeffrey Kirsch, P. D. Hurn, W. S P Toung, R. J. Traystman

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The effect of transient postischemic hypothermia (30°C) on recovery of cerebral blood flow (CBF), oxygen consumption (CMRO2) and somatosensory-evoked potentials (SEPs) was determined in anesthetized dogs. Ischemia was produced for 20 min by intracranial pressure (ICP) elevation while core temperature was lowered by cooling externalized blood. Epidural temperature was controlled at 37.6 ± 0.2°C during ischemia, lowered to 30.0 ± 0.1°C during the first hour of reperfusion, and then rewarmed to 38.0 ± 0.1°C in experimental dogs (n = 8) and maintained at 38.0 ± 0.1°C in control dogs (n = 8). ICP was lower throughout reperfusion in experimental as compared with control animals. By 240 min of reperfusion, CBF was ~70% of control in both groups. CMRO2 was 60% of preischemic values in control animals and 74% in experimental animals (P = 0.077). A persistent uncoupling of CBF and CMRO2 was observed throughout reperfusion only in the control group. Recovery of SEP amplitude was significantly improved in the experimental group (26 vs. 11% of preischemic values). These data suggest that transient hypothermia reduces ICP and facilitates recovery of electrophysiological function after cerebral ischemia.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume261
Issue number3 30-3
StatePublished - 1991
Externally publishedYes

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Cerebrovascular Circulation
Reperfusion
Ischemia
Somatosensory Evoked Potentials
Intracranial Pressure
Dogs
Hypothermia
Temperature
Intracranial Hypertension
Recovery of Function
Brain Ischemia
Oxygen Consumption
Control Groups

Keywords

  • Cerebral blood flow
  • Cerebral metabolism
  • Hypothermia

ASJC Scopus subject areas

  • Physiology

Cite this

Hypothermic cerebral reperfusion and recovery from ischemia. / Baldwin, W. A.; Kirsch, Jeffrey; Hurn, P. D.; Toung, W. S P; Traystman, R. J.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 261, No. 3 30-3, 1991.

Research output: Contribution to journalArticle

Baldwin, W. A. ; Kirsch, Jeffrey ; Hurn, P. D. ; Toung, W. S P ; Traystman, R. J. / Hypothermic cerebral reperfusion and recovery from ischemia. In: American Journal of Physiology - Heart and Circulatory Physiology. 1991 ; Vol. 261, No. 3 30-3.
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