Hypothalamic site-dependent effects of neuropeptide Y on gonadotropin-releasing hormone secretion in rhesus macaques

K. Y F Pau, M. Berria, David Hess, H. G. Spies

    Research output: Contribution to journalArticle

    48 Citations (Scopus)

    Abstract

    In rodents and rabbits, neuropeptide Y (NPY) has a bimodal effect on gonadotropin-releasing hormone (GnRH) secretion. Intracerebroventricular (icv) administration or direct infusion of NPY into the median eminence (ime) suppresses GnRH release in ovariectomized (OVX) animals, but stimulates GnRH release in intact or OVX animals treated with ovarian steroids. Specific ovarian steroid-dependent NPY effects are, however, not obvious in non-human primates. In OVX rhesus monkeys, icv administration of NPY has been shown to suppress luteinizing hormone (LH) secretion whereas ime infusion of NPY stimulates GnRH pulses. In such animals, estrogen replacement does not reverse the inhibitory NPY effect on LH release, although estrogen enhances the stimulatory NPY effect on GnRH secretion. These observations led us to speculate that the bimodal NPY effects in non-human primates may depend on either the site of NPY action or the nature of the steroid milieu. This study utilized the push-pull perfusion (PPP) technique to examine the effects of either ime or icv infusion of NPY on GnRH release in OVX monkeys treated with or without both ovarian steroids. Without exception, ime infusion of NPY increased GnRH concentrations in push-pull perfusates regardless of the steroid status of the animals. In contrast, GnRH levels were reduced during icv infusion of NPY in both untreated and estrogen/progesterone-treated, OVX monkeys. These results indicate that, unlike other mammalian species, in the rhesus monkey the stimulatory and inhibitory effects of NPY on GnRH release depend on the site of NPY infusion within the brain rather than the ovarian steroidal environment.

    Original languageEnglish (US)
    Pages (from-to)63-67
    Number of pages5
    JournalJournal of Neuroendocrinology
    Volume7
    Issue number1
    DOIs
    StatePublished - 1995

    Fingerprint

    Neuropeptide Y
    Macaca mulatta
    Gonadotropin-Releasing Hormone
    Median Eminence
    Steroids
    Intraventricular Infusions
    Luteinizing Hormone
    Primates
    Haplorhini
    Estrogens
    Estrogen Replacement Therapy
    Progesterone
    Rodentia

    Keywords

    • GnRH
    • Hypothalamus
    • LH
    • Monkey
    • NPY
    • Steroids

    ASJC Scopus subject areas

    • Endocrinology
    • Neuroscience(all)

    Cite this

    Hypothalamic site-dependent effects of neuropeptide Y on gonadotropin-releasing hormone secretion in rhesus macaques. / Pau, K. Y F; Berria, M.; Hess, David; Spies, H. G.

    In: Journal of Neuroendocrinology, Vol. 7, No. 1, 1995, p. 63-67.

    Research output: Contribution to journalArticle

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