Hypothalamic serotonin in treatments for feeding disorders and depression as studied by brain microdialysis

L. Hernandez, M. Parada, T. Baptista, D. Schwartz, H. L. West, Gregory Mark, B. G. Hoebel

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Microdialysis was used to measure changes in extracellular serotonin in the hypothalamus of rats while they engaged in feeding behavior or received drug treatments used to treat feeding disorders and affective disorders in humans. Hypothalamic serotonin increased significantly relative to controls in response to (1) intraperitoneal tryptophan after food deprivation, (2) the smell of food and eating a meal, (3) a conditioned taste aversion, (4) d-fenfluramine and fluoxetine, and (5) an amphetamine challenge test after chronic low doses of lithium. In some cases, increases correlated with nonspecific behavioral arousal were seen in the hippocampus. The results suggest that diet, drug, and behavioral therapies, alone or combined, can be used to preferentially modify hypothalamic serotonin in the control of behavioral, emotional, and endocrine problems.

Original languageEnglish (US)
Pages (from-to)32-40
Number of pages9
JournalJournal of Clinical Psychiatry
Volume52
Issue number12 SUPPL.
StatePublished - 1991
Externally publishedYes

Fingerprint

Microdialysis
Serotonin
Depression
Brain
Fenfluramine
Food Deprivation
Smell
Fluoxetine
Feeding Behavior
Amphetamine
Arousal
Mood Disorders
Lithium
Tryptophan
Hypothalamus
Meals
Hippocampus
Therapeutics
Eating
Diet

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Hernandez, L., Parada, M., Baptista, T., Schwartz, D., West, H. L., Mark, G., & Hoebel, B. G. (1991). Hypothalamic serotonin in treatments for feeding disorders and depression as studied by brain microdialysis. Journal of Clinical Psychiatry, 52(12 SUPPL.), 32-40.

Hypothalamic serotonin in treatments for feeding disorders and depression as studied by brain microdialysis. / Hernandez, L.; Parada, M.; Baptista, T.; Schwartz, D.; West, H. L.; Mark, Gregory; Hoebel, B. G.

In: Journal of Clinical Psychiatry, Vol. 52, No. 12 SUPPL., 1991, p. 32-40.

Research output: Contribution to journalArticle

Hernandez, L, Parada, M, Baptista, T, Schwartz, D, West, HL, Mark, G & Hoebel, BG 1991, 'Hypothalamic serotonin in treatments for feeding disorders and depression as studied by brain microdialysis', Journal of Clinical Psychiatry, vol. 52, no. 12 SUPPL., pp. 32-40.
Hernandez L, Parada M, Baptista T, Schwartz D, West HL, Mark G et al. Hypothalamic serotonin in treatments for feeding disorders and depression as studied by brain microdialysis. Journal of Clinical Psychiatry. 1991;52(12 SUPPL.):32-40.
Hernandez, L. ; Parada, M. ; Baptista, T. ; Schwartz, D. ; West, H. L. ; Mark, Gregory ; Hoebel, B. G. / Hypothalamic serotonin in treatments for feeding disorders and depression as studied by brain microdialysis. In: Journal of Clinical Psychiatry. 1991 ; Vol. 52, No. 12 SUPPL. pp. 32-40.
@article{12df0b7c27e140268989b6db3d78ddb7,
title = "Hypothalamic serotonin in treatments for feeding disorders and depression as studied by brain microdialysis",
abstract = "Microdialysis was used to measure changes in extracellular serotonin in the hypothalamus of rats while they engaged in feeding behavior or received drug treatments used to treat feeding disorders and affective disorders in humans. Hypothalamic serotonin increased significantly relative to controls in response to (1) intraperitoneal tryptophan after food deprivation, (2) the smell of food and eating a meal, (3) a conditioned taste aversion, (4) d-fenfluramine and fluoxetine, and (5) an amphetamine challenge test after chronic low doses of lithium. In some cases, increases correlated with nonspecific behavioral arousal were seen in the hippocampus. The results suggest that diet, drug, and behavioral therapies, alone or combined, can be used to preferentially modify hypothalamic serotonin in the control of behavioral, emotional, and endocrine problems.",
author = "L. Hernandez and M. Parada and T. Baptista and D. Schwartz and West, {H. L.} and Gregory Mark and Hoebel, {B. G.}",
year = "1991",
language = "English (US)",
volume = "52",
pages = "32--40",
journal = "Journal of Clinical Psychiatry",
issn = "0160-6689",
publisher = "Physicians Postgraduate Press Inc.",
number = "12 SUPPL.",

}

TY - JOUR

T1 - Hypothalamic serotonin in treatments for feeding disorders and depression as studied by brain microdialysis

AU - Hernandez, L.

AU - Parada, M.

AU - Baptista, T.

AU - Schwartz, D.

AU - West, H. L.

AU - Mark, Gregory

AU - Hoebel, B. G.

PY - 1991

Y1 - 1991

N2 - Microdialysis was used to measure changes in extracellular serotonin in the hypothalamus of rats while they engaged in feeding behavior or received drug treatments used to treat feeding disorders and affective disorders in humans. Hypothalamic serotonin increased significantly relative to controls in response to (1) intraperitoneal tryptophan after food deprivation, (2) the smell of food and eating a meal, (3) a conditioned taste aversion, (4) d-fenfluramine and fluoxetine, and (5) an amphetamine challenge test after chronic low doses of lithium. In some cases, increases correlated with nonspecific behavioral arousal were seen in the hippocampus. The results suggest that diet, drug, and behavioral therapies, alone or combined, can be used to preferentially modify hypothalamic serotonin in the control of behavioral, emotional, and endocrine problems.

AB - Microdialysis was used to measure changes in extracellular serotonin in the hypothalamus of rats while they engaged in feeding behavior or received drug treatments used to treat feeding disorders and affective disorders in humans. Hypothalamic serotonin increased significantly relative to controls in response to (1) intraperitoneal tryptophan after food deprivation, (2) the smell of food and eating a meal, (3) a conditioned taste aversion, (4) d-fenfluramine and fluoxetine, and (5) an amphetamine challenge test after chronic low doses of lithium. In some cases, increases correlated with nonspecific behavioral arousal were seen in the hippocampus. The results suggest that diet, drug, and behavioral therapies, alone or combined, can be used to preferentially modify hypothalamic serotonin in the control of behavioral, emotional, and endocrine problems.

UR - http://www.scopus.com/inward/record.url?scp=0026326488&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026326488&partnerID=8YFLogxK

M3 - Article

VL - 52

SP - 32

EP - 40

JO - Journal of Clinical Psychiatry

JF - Journal of Clinical Psychiatry

SN - 0160-6689

IS - 12 SUPPL.

ER -