Abstract
Anorexia is a common symptom in chronic illness. It contributes to malnutrition and strongly affects survival and quality of life. A common denominator of many chronic diseases is an elevated inflammatory status, which is considered to play a pivotal role in the failure of food-intake regulating systems in the hypothalamus. In this review, we summarize findings on the role of hypothalamic inflammation on food intake regulation involving hypothalamic neuropeptide Y (NPY) and pro-opiomelanocortin (POMC). Furthermore, we outline the role of serotonin in the inability of these peptide based food-intake regulating systems to respond and adapt to changes in energy metabolism during chronic disease.
Original language | English (US) |
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Pages (from-to) | 60-66 |
Number of pages | 7 |
Journal | Peptides |
Volume | 77 |
DOIs | |
State | Published - Mar 1 2016 |
Keywords
- Anorexia
- Hypothalamus
- Inflammation
- Melanocortins
- NPY
- Serotonin
ASJC Scopus subject areas
- Biochemistry
- Physiology
- Endocrinology
- Cellular and Molecular Neuroscience