Hypothalamic inflammation and food intake regulation during chronic illness

J. T. Dwarkasing, Daniel Marks, R. F. Witkamp, K. Van Norren

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Anorexia is a common symptom in chronic illness. It contributes to malnutrition and strongly affects survival and quality of life. A common denominator of many chronic diseases is an elevated inflammatory status, which is considered to play a pivotal role in the failure of food-intake regulating systems in the hypothalamus. In this review, we summarize findings on the role of hypothalamic inflammation on food intake regulation involving hypothalamic neuropeptide Y (NPY) and pro-opiomelanocortin (POMC). Furthermore, we outline the role of serotonin in the inability of these peptide based food-intake regulating systems to respond and adapt to changes in energy metabolism during chronic disease.

Original languageEnglish (US)
Pages (from-to)60-66
Number of pages7
JournalPeptides
Volume77
DOIs
StatePublished - Mar 1 2016

Fingerprint

Appetite Regulation
Chronic Disease
Inflammation
Eating
Pro-Opiomelanocortin
Neuropeptide Y
Anorexia
Malnutrition
Energy Metabolism
Hypothalamus
Serotonin
Quality of Life
Peptides

Keywords

  • Anorexia
  • Hypothalamus
  • Inflammation
  • Melanocortins
  • NPY
  • Serotonin

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Hypothalamic inflammation and food intake regulation during chronic illness. / Dwarkasing, J. T.; Marks, Daniel; Witkamp, R. F.; Van Norren, K.

In: Peptides, Vol. 77, 01.03.2016, p. 60-66.

Research output: Contribution to journalArticle

Dwarkasing, J. T. ; Marks, Daniel ; Witkamp, R. F. ; Van Norren, K. / Hypothalamic inflammation and food intake regulation during chronic illness. In: Peptides. 2016 ; Vol. 77. pp. 60-66.
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