Hypothalamic hamartoma

a paradigm/model for studying the onset of puberty.

Heike Jung, Anne Simone Parent, Sergio Ojeda

    Research output: Contribution to journalArticle

    14 Citations (Scopus)

    Abstract

    This article discusses the potential mechanisms by which hypothalamic hamartomas (HHs) are formed and cause precocious puberty. The hypothesis is presented suggesting that HHs accelerate sexual development by producing bioactive substances that mimic - in an accelerated time-course - the cascade of events underlying the normal initiation of puberty. It is also proposed that because HHs contain key transcriptional and signaling networks required to initiate and sustain a pubertal mode of gonadotropin-releasing hormone (GnRH) release, they are able to trigger the pubertal process at an earlier age. The cellular components of this activating complex may include: (a) neurons able to produce GnRH within the HH: (b) controlling neurons synaptically connected to GnRH neurons in the HH itself and/or to neuronal networks (including GnRH neurons) in the patient's hypothalamus, and (c) signaling-competent astrocytic and ependymoglial cells. It is also possible that the developmental abnormalities leading to the formation of HHs result from sporadic defects affecting the same genes and hence the same morphogenic pathways involved in the embryonic development of the ventral hypothalamus and the floor of the third ventricle.

    Original languageEnglish (US)
    Pages (from-to)81-93
    Number of pages13
    JournalEndocrine Development
    Volume8
    StatePublished - 2005

    Fingerprint

    Puberty
    Gonadotropin-Releasing Hormone
    Neurons
    Hypothalamus
    Ependymoglial Cells
    Precocious Puberty
    Sexual Development
    Third Ventricle
    Gene Regulatory Networks
    Embryonic Development
    Hypothalamic hamartomas
    Genes

    Cite this

    Hypothalamic hamartoma : a paradigm/model for studying the onset of puberty. / Jung, Heike; Parent, Anne Simone; Ojeda, Sergio.

    In: Endocrine Development, Vol. 8, 2005, p. 81-93.

    Research output: Contribution to journalArticle

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