Hyponatremia and fractures: Findings from the MrOS study

Sophie A. Jamal, Spyridon Arampatzis, Stephanie Litwack Harrison, Roxana C. Bucur, Kristine Ensrud, Eric Orwoll, Douglas C. Bauer

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Hyponatremia may be a risk factor for fracture. To determine the relationship between hyponatremia and fracture we conducted cross-sectional and longitudinal analyses using data from the Osteoporotic Fractures in Men (MrOS) study. The MrOS study enrolled 5122 community dwelling men aged ≥65 years from six centers across the United States. We excluded men taking bisphosphonates, those with unknown medication history, those without serum sodium measures, or those with out of range assays for serum sodium. Serum sodium was measured at study entry. Subjects were followed for fractures (nonspine [including hip], hip, incident morphometric, and prevalent morphometric) for up to 9 years. We used Cox proportional hazards models to analyze the association between serum sodium levels (

Original languageEnglish (US)
Pages (from-to)970-975
Number of pages6
JournalJournal of Bone and Mineral Research
Volume30
Issue number6
DOIs
Publication statusPublished - Jun 1 2015

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Keywords

  • DXA
  • FRACTURE RISK ASSESSMENT
  • GENERAL POPULATION STUDIES
  • OSTEOPOROSIS
  • SYSTEMS BIOLOGY - BONE INTERACTIONS

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Jamal, S. A., Arampatzis, S., Harrison, S. L., Bucur, R. C., Ensrud, K., Orwoll, E., & Bauer, D. C. (2015). Hyponatremia and fractures: Findings from the MrOS study. Journal of Bone and Mineral Research, 30(6), 970-975. https://doi.org/10.1002/jbmr.2383