Hypomethylation of the IL17RC Promoter Associates with Age-Related Macular Degeneration

Lai Wei, Baoying Liu, Jingsheng Tuo, Defen Shen, Ping Chen, Zhiyu Li, Xunxian Liu, Jia Ni, Pradeep Dagur, H. Nida Sen, Shayma Jawad, Diamond Ling, Stanley Park, Sagarika Chakrabarty, Catherine Meyerle, Elvira Agron, Frederick L. Ferris, Emily Y. Chew, J. Philip McCoy, Emily Blum & 6 others Peter J. Francis, Michael Klein, Robyn H. Guymer, Paul N. Baird, Chi Chao Chan, Robert B. Nussenblatt

Research output: Contribution to journalArticle

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Abstract

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly population worldwide. Although recent studies have demonstrated strong genetic associations between AMD and SNPs in a number of genes, other modes of regulation are also likely to play a role in the etiology of this disease. We identified a significantly decreased level of methylation on the IL17RC promoter in AMD patients. Furthermore, we showed that hypomethylation of the IL17RC promoter in AMD patients led to an elevated expression of its protein and messenger RNA in peripheral blood as well as in the affected retina and choroid, suggesting that the DNA methylation pattern and expression of IL17RC may potentially serve as a biomarker for the diagnosis of AMD and likely plays a role in disease pathogenesis.

Original languageEnglish (US)
Pages (from-to)1151-1158
Number of pages8
JournalCell Reports
Volume2
Issue number5
DOIs
StatePublished - Nov 29 2012

Fingerprint

Macular Degeneration
Methylation
Biomarkers
Blood
Genes
Messenger RNA
Choroid
DNA Methylation
Blindness
Proteins
Single Nucleotide Polymorphism
Retina
Population

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Wei, L., Liu, B., Tuo, J., Shen, D., Chen, P., Li, Z., ... Nussenblatt, R. B. (2012). Hypomethylation of the IL17RC Promoter Associates with Age-Related Macular Degeneration. Cell Reports, 2(5), 1151-1158. https://doi.org/10.1016/j.celrep.2012.10.013

Hypomethylation of the IL17RC Promoter Associates with Age-Related Macular Degeneration. / Wei, Lai; Liu, Baoying; Tuo, Jingsheng; Shen, Defen; Chen, Ping; Li, Zhiyu; Liu, Xunxian; Ni, Jia; Dagur, Pradeep; Sen, H. Nida; Jawad, Shayma; Ling, Diamond; Park, Stanley; Chakrabarty, Sagarika; Meyerle, Catherine; Agron, Elvira; Ferris, Frederick L.; Chew, Emily Y.; McCoy, J. Philip; Blum, Emily; Francis, Peter J.; Klein, Michael; Guymer, Robyn H.; Baird, Paul N.; Chan, Chi Chao; Nussenblatt, Robert B.

In: Cell Reports, Vol. 2, No. 5, 29.11.2012, p. 1151-1158.

Research output: Contribution to journalArticle

Wei, L, Liu, B, Tuo, J, Shen, D, Chen, P, Li, Z, Liu, X, Ni, J, Dagur, P, Sen, HN, Jawad, S, Ling, D, Park, S, Chakrabarty, S, Meyerle, C, Agron, E, Ferris, FL, Chew, EY, McCoy, JP, Blum, E, Francis, PJ, Klein, M, Guymer, RH, Baird, PN, Chan, CC & Nussenblatt, RB 2012, 'Hypomethylation of the IL17RC Promoter Associates with Age-Related Macular Degeneration', Cell Reports, vol. 2, no. 5, pp. 1151-1158. https://doi.org/10.1016/j.celrep.2012.10.013
Wei, Lai ; Liu, Baoying ; Tuo, Jingsheng ; Shen, Defen ; Chen, Ping ; Li, Zhiyu ; Liu, Xunxian ; Ni, Jia ; Dagur, Pradeep ; Sen, H. Nida ; Jawad, Shayma ; Ling, Diamond ; Park, Stanley ; Chakrabarty, Sagarika ; Meyerle, Catherine ; Agron, Elvira ; Ferris, Frederick L. ; Chew, Emily Y. ; McCoy, J. Philip ; Blum, Emily ; Francis, Peter J. ; Klein, Michael ; Guymer, Robyn H. ; Baird, Paul N. ; Chan, Chi Chao ; Nussenblatt, Robert B. / Hypomethylation of the IL17RC Promoter Associates with Age-Related Macular Degeneration. In: Cell Reports. 2012 ; Vol. 2, No. 5. pp. 1151-1158.
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abstract = "Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly population worldwide. Although recent studies have demonstrated strong genetic associations between AMD and SNPs in a number of genes, other modes of regulation are also likely to play a role in the etiology of this disease. We identified a significantly decreased level of methylation on the IL17RC promoter in AMD patients. Furthermore, we showed that hypomethylation of the IL17RC promoter in AMD patients led to an elevated expression of its protein and messenger RNA in peripheral blood as well as in the affected retina and choroid, suggesting that the DNA methylation pattern and expression of IL17RC may potentially serve as a biomarker for the diagnosis of AMD and likely plays a role in disease pathogenesis.",
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T1 - Hypomethylation of the IL17RC Promoter Associates with Age-Related Macular Degeneration

AU - Wei, Lai

AU - Liu, Baoying

AU - Tuo, Jingsheng

AU - Shen, Defen

AU - Chen, Ping

AU - Li, Zhiyu

AU - Liu, Xunxian

AU - Ni, Jia

AU - Dagur, Pradeep

AU - Sen, H. Nida

AU - Jawad, Shayma

AU - Ling, Diamond

AU - Park, Stanley

AU - Chakrabarty, Sagarika

AU - Meyerle, Catherine

AU - Agron, Elvira

AU - Ferris, Frederick L.

AU - Chew, Emily Y.

AU - McCoy, J. Philip

AU - Blum, Emily

AU - Francis, Peter J.

AU - Klein, Michael

AU - Guymer, Robyn H.

AU - Baird, Paul N.

AU - Chan, Chi Chao

AU - Nussenblatt, Robert B.

PY - 2012/11/29

Y1 - 2012/11/29

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AB - Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly population worldwide. Although recent studies have demonstrated strong genetic associations between AMD and SNPs in a number of genes, other modes of regulation are also likely to play a role in the etiology of this disease. We identified a significantly decreased level of methylation on the IL17RC promoter in AMD patients. Furthermore, we showed that hypomethylation of the IL17RC promoter in AMD patients led to an elevated expression of its protein and messenger RNA in peripheral blood as well as in the affected retina and choroid, suggesting that the DNA methylation pattern and expression of IL17RC may potentially serve as a biomarker for the diagnosis of AMD and likely plays a role in disease pathogenesis.

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