Hypogonadism in chronically lead-poisoned men

G. D. Braunstein, J. Dahlgren, Donald (Lynn) Loriaux

Research output: Contribution to journalArticle

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Abstract

The hypothalamic-pituitary-testicular axis was evaluated in ten men with occupational lead exposure, nine of whom had noted a decrease in libido and frequency of intercourse following this exposure. Six of these men had clinically apparent lead-poisoning while four were classified as being only lead-exposed. The results of the endocrine evaluation of these patients were compared to those obtained on nine age and socioeconomically matched control patients. Both lead-poisoned and lead-exposed patients had reduced basal serum testosterone levels and normal basal serum testosterone-estradiol-binding globulin capacity, estradiol, LH, FSH, and prolactin levels. Both groups demonstrated an appropriate rise in serum testosterone following hCG stimulation and a normal increment in serum FSH in response to clomiphene citrate and gonadotropin-releasing hormone in comparison to the control group. The lead-poisoned patients demonstrated a significantly reduced increment in serum LH after clomiphene citrate and gonadotropin-releasing hormone administration while the lead-exposed patients had normal LH dynamics. Testicular biopsies carried out on the two most severely lead-poisoned men demonstrated peritubular fibrosis, oligospermia and vacuolization of the Sertoli cells. These results suggest that lead poisoning may lead to a pituitary-hypothalamic defect in LH secretion and may also result in direct testicular seminiferous tubular injury.

Original languageEnglish (US)
Pages (from-to)33-51
Number of pages19
JournalInfertility
Volume1
Issue number1
StatePublished - 1978
Externally publishedYes

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Hypogonadism
Lead Poisoning
Clomiphene
Serum
Gonadotropin-Releasing Hormone
Testosterone
Oligospermia
Serum Globulins
Libido
Sex Hormone-Binding Globulin
Sertoli Cells
Occupational Exposure
Lead
Prolactin
Estradiol
Fibrosis
Biopsy
Control Groups
Wounds and Injuries

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Braunstein, G. D., Dahlgren, J., & Loriaux, D. L. (1978). Hypogonadism in chronically lead-poisoned men. Infertility, 1(1), 33-51.

Hypogonadism in chronically lead-poisoned men. / Braunstein, G. D.; Dahlgren, J.; Loriaux, Donald (Lynn).

In: Infertility, Vol. 1, No. 1, 1978, p. 33-51.

Research output: Contribution to journalArticle

Braunstein, GD, Dahlgren, J & Loriaux, DL 1978, 'Hypogonadism in chronically lead-poisoned men', Infertility, vol. 1, no. 1, pp. 33-51.
Braunstein GD, Dahlgren J, Loriaux DL. Hypogonadism in chronically lead-poisoned men. Infertility. 1978;1(1):33-51.
Braunstein, G. D. ; Dahlgren, J. ; Loriaux, Donald (Lynn). / Hypogonadism in chronically lead-poisoned men. In: Infertility. 1978 ; Vol. 1, No. 1. pp. 33-51.
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