Hypoglycemia Reduction and Changes in Hemoglobin A1c in the ASPIRE In-Home Study

Ram Weiss, Satish K. Garg, Bruce W. Bode, Timothy S. Bailey, Andrew Ahmann, Kenneth A. Schultz, John B. Welsh, John J. Shin

Research output: Contribution to journalArticle

30 Scopus citations


Background: ASPIRE In-Home randomized 247 subjects with type 1 diabetes to sensor-augmented pump therapy with or without the Threshold Suspend (TS) feature, which interrupts insulin delivery at a preset sensor glucose value. We studied the effects of TS on nocturnal hypoglycemia (NH) in relation to baseline hemoglobin A1c (A1C) and change in A1C during the study. Materials and Methods: NH event rates and mean area under curve (AUC) of NH events were evaluated at different levels of baseline A1C (8%) and at different levels of changes in A1C (less than -0.3% [decreased], -0.3% to 0.3% [stable], and >0.3% [increased]), in the TS Group compared with the Control Group (sensor-augmented pump only). Results: In the TS Group, 27.9% of the NH events were accompanied by a confirmatory blood glucose value, compared with 39.3% in the Control Group. Among subjects with baseline A1C levels of

Original languageEnglish (US)
Pages (from-to)542-547
Number of pages6
JournalDiabetes Technology and Therapeutics
Issue number8
Publication statusPublished - Aug 1 2015


ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Medical Laboratory Technology

Cite this

Weiss, R., Garg, S. K., Bode, B. W., Bailey, T. S., Ahmann, A., Schultz, K. A., ... Shin, J. J. (2015). Hypoglycemia Reduction and Changes in Hemoglobin A1c in the ASPIRE In-Home Study. Diabetes Technology and Therapeutics, 17(8), 542-547. https://doi.org/10.1089/dia.2014.0306