Hyphal forms in the central nervous system of patients with coccidioidomycosis

Heidi M. Hagman, Ellen G. Madnick, Anthony N. D'Agostino, Paul L. Williams, Stanley Shatsky, Laurence F. Mirels, Richard M. Tucker, Michael G. Rinaldi, David A. Stevens, Richard Bryant

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Coccidioides immitis is a dimorphic fungus that grows as a filamentous mold in soil and as a spherule at human body temperature. The hyphal or soil form is found rarely in human tissue. We report 5 cases of coccidioidomycosis in which hyphae were found in brain tissue or spinal fluid. The presence of central nervous system plastic devices appears to be associated with morphological reversion to the saprophytic form. This reversion has implications for diagnosis and therapy and may increase the risk of obstruction of the device(s).

Original languageEnglish (US)
Pages (from-to)349-355
Number of pages7
JournalClinical Infectious Diseases
Volume30
Issue number2
DOIs
StatePublished - 2000

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Coccidioidomycosis
Fungi
Soil
Central Nervous System
Coccidioides
Equipment and Supplies
Hyphae
Body Temperature
Human Body
Plastics
Brain
Therapeutics

ASJC Scopus subject areas

  • Immunology

Cite this

Hagman, H. M., Madnick, E. G., D'Agostino, A. N., Williams, P. L., Shatsky, S., Mirels, L. F., ... Bryant, R. (2000). Hyphal forms in the central nervous system of patients with coccidioidomycosis. Clinical Infectious Diseases, 30(2), 349-355. https://doi.org/10.1086/313643

Hyphal forms in the central nervous system of patients with coccidioidomycosis. / Hagman, Heidi M.; Madnick, Ellen G.; D'Agostino, Anthony N.; Williams, Paul L.; Shatsky, Stanley; Mirels, Laurence F.; Tucker, Richard M.; Rinaldi, Michael G.; Stevens, David A.; Bryant, Richard.

In: Clinical Infectious Diseases, Vol. 30, No. 2, 2000, p. 349-355.

Research output: Contribution to journalArticle

Hagman, HM, Madnick, EG, D'Agostino, AN, Williams, PL, Shatsky, S, Mirels, LF, Tucker, RM, Rinaldi, MG, Stevens, DA & Bryant, R 2000, 'Hyphal forms in the central nervous system of patients with coccidioidomycosis', Clinical Infectious Diseases, vol. 30, no. 2, pp. 349-355. https://doi.org/10.1086/313643
Hagman HM, Madnick EG, D'Agostino AN, Williams PL, Shatsky S, Mirels LF et al. Hyphal forms in the central nervous system of patients with coccidioidomycosis. Clinical Infectious Diseases. 2000;30(2):349-355. https://doi.org/10.1086/313643
Hagman, Heidi M. ; Madnick, Ellen G. ; D'Agostino, Anthony N. ; Williams, Paul L. ; Shatsky, Stanley ; Mirels, Laurence F. ; Tucker, Richard M. ; Rinaldi, Michael G. ; Stevens, David A. ; Bryant, Richard. / Hyphal forms in the central nervous system of patients with coccidioidomycosis. In: Clinical Infectious Diseases. 2000 ; Vol. 30, No. 2. pp. 349-355.
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