Hypertonic saline and mannitol therapy in critical care neurology

Holly Hinson, Deborah Stein, Kevin N. Sheth

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Osmotic agents play a vital role in the reduction of elevated intracranial pressure and treatment of cerebral edema in Neurologic critical care. Both mannitol and hypertonic saline reduce cerebral edema in many clinical syndromes, yet there is controversy over agent selection, timing, and dosing regimens. Despite the lack of randomized, controlled trials, our knowledge base on the appropriate clinical use of osmotic agents continues to expand. This review will summarize the evidence for the use of mannitol and hypertonic saline in a variety of disease states causing cerebral edema, as well as outlining monitoring and safety considerations.

Original languageEnglish (US)
Pages (from-to)3-11
Number of pages9
JournalJournal of Intensive Care Medicine
Volume28
Issue number1
DOIs
StatePublished - Jan 2013
Externally publishedYes

Fingerprint

Brain Edema
Mannitol
Critical Care
Neurology
Intracranial Hypertension
Knowledge Bases
Nervous System
Therapeutics
Randomized Controlled Trials
Safety

Keywords

  • Cerebral edema
  • Hypertonic saline
  • Mannitol
  • Osmotic therapy

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Hypertonic saline and mannitol therapy in critical care neurology. / Hinson, Holly; Stein, Deborah; Sheth, Kevin N.

In: Journal of Intensive Care Medicine, Vol. 28, No. 1, 01.2013, p. 3-11.

Research output: Contribution to journalArticle

Hinson, Holly ; Stein, Deborah ; Sheth, Kevin N. / Hypertonic saline and mannitol therapy in critical care neurology. In: Journal of Intensive Care Medicine. 2013 ; Vol. 28, No. 1. pp. 3-11.
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