Hyperthermic Treatment of Intraocular Tumors

Paul T. Finger, Samuel Packer, Paul P. Svitra, Robert W. Paglione, Jeremy Chess, Daniel M. Albert

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

A 5.8-gigahertz (GHz) ophthalmic microwave applicator was used to treat choroidal melanoma (Greene strain) in rabbits. High-frequency electromagnetic radiation provides a favorable dose distribution to induce local hyperthermia in the treatment of intraocular tumors. Heating of the neoplasm, while sparing normal ocular structures, is best accomplished by a transscleral approach. A hyperthermia plaque is placed on the sclera at the base of the intraocular tumor. Contact (resistive) heating and electromagnetic radiation (radiofrequency and microwave) are best suited to a plaque technique. The advantages of electromagnetic heat induction, as compared with contact heating, are twofold: The depth of hyperthermic penetration can be modulated by frequency selection, and the tissues with low water content (sclera) remain relatively unaffected by microwaves. The 5.8-GHz ophthalmic microwave applicator satisfies the requirements for local hyperthermic treatment of intraocular tumors.

Original languageEnglish (US)
Pages (from-to)1477-1481
Number of pages5
JournalArchives of ophthalmology
Volume102
Issue number10
DOIs
StatePublished - Oct 1984

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ASJC Scopus subject areas

  • Ophthalmology

Cite this

Finger, P. T., Packer, S., Svitra, P. P., Paglione, R. W., Chess, J., & Albert, D. M. (1984). Hyperthermic Treatment of Intraocular Tumors. Archives of ophthalmology, 102(10), 1477-1481. https://doi.org/10.1001/archopht.1984.01040031197017