Hypersensitivity reactions to non-beta-lactam antibiotics

Stephen A. Tilles, Christopher G. Slatore

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


As alternatives to beta lactam antibiotics continue to be developed, an increasing number of patients are experiencing hypersensitivity reactions to these agents. Unfortunately, unlike penicillin, there are no validated skin testing reagents to aid in confirming the presence of specific IgE antibodies to these drugs. This review summarizes what is known about hypersensitivity reactions to non-beta lactam antibiotics, and includes practical approaches to readministering these drugs in selected situations. Sulfonamides, vancomycin, macrolides, tetracyclines, fluoroquinolones, and anti-virals are included in the discussion.

Original languageEnglish (US)
Pages (from-to)221-228
Number of pages8
JournalClinical Reviews in Allergy and Immunology
Issue number3
StatePublished - Jun 2003
Externally publishedYes


  • Anti-virals
  • Fluoroquinolones
  • Macrolides
  • Sulfonamides
  • Tetracyclines
  • Vancomycin

ASJC Scopus subject areas

  • Immunology and Allergy


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