Hypermethylation at a chromosome 17 "Hot spot" is a common event in ovarian cancer

Maura Pieretti, Deborah E. Powell, Holly H. Gallion, Pamela S. Conway, Elizabeth A. Case, Mitchell S. Turker

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Alterations of normal DNA methylation patterns have been reported in various types of human tumors. These alterations are represented by genome wide hypomethylation and by region specific hyper methylation. One commonly hypermethylated region is 17p13.3 (D17S5), the putative site of a tumor suppressor gene. In this study we report that hypermethylation at this locus occurs frequently (33%) in ovarian tumors. We reported previously that loss of chromosome 17 is a common event in serous epithelial ovarian tumors. A correlation of the methylation event and chromosome 17 loss suggests that hypermethylation at D17S5 precedes chromosome 17 loss.

Original languageEnglish (US)
Pages (from-to)398-401
Number of pages4
JournalHuman Pathology
Volume26
Issue number4
DOIs
StatePublished - Apr 1995
Externally publishedYes

Keywords

  • chromosome 17
  • hypermethylation
  • ovarian tumors

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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