Hypercapnia can induce arousal from sleep in the absence of altered respiratory mechanoreception

N. T. Ayas, R. Brown, Steven Shea

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Possible mechanisms of arousal from respiratory stimuli include changes in PO2, PCO2, central respiratory drive, or respiratory mechanoreceptor activity. We sought to determine whether hypercapnia alone could induce arousal from sleep in four subjects with high (≥ C3) neurologically complete spinal cord injuries while on constant positive pressure mechanical ventilation (hence, respiratory mechanoreceptor activity remained constant). Subjects were chronically hypocapnic (mean baseline PET(CO2) = 21 mm Hg; range, 13-30 mm Hg). On the first night, the baseline rate of spontaneous awakenings was determined by polysomnography. On night two, FI(CO2) was increased rapidly in stable NREM sleep. Awakenings occurred in 19 of 19 trials within 5 min, with each subject waking and complaining of shortness of breath (mean time to arousal, 115 s; range, 26-264 s). It is unlikely that these were spontaneous, as the times to awakening during hypercapnia were much higher than during baseline conditions (p <0.05). During rapidly induced hypercapnia, PET(CO2) overestimates the PCO2 at the central chemoreceptors. To determine more precisely the PET(CO2) arousal threshold, PET(CO2) was increased slowly (approximately 2 mm Hg/min); arousal occurred at a mean PET(CO2) of 37 mm Hg (range, 23-45 mm Hg; mean change from baseline, 15.8 mm Hg, range, 10-20 mm Hg). Hence, both rapid and slow increases in PET(CO2) can induce arousal in humans in the absence of changes in respiratory mechanoreceptor activity.

Original languageEnglish (US)
Pages (from-to)1004-1008
Number of pages5
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume162
Issue number3 I
StatePublished - 2000
Externally publishedYes

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Hypercapnia
Arousal
Sleep
Mechanoreceptors
Positive-Pressure Respiration
Polysomnography
Spinal Cord Injuries
Artificial Respiration
Dyspnea

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Hypercapnia can induce arousal from sleep in the absence of altered respiratory mechanoreception. / Ayas, N. T.; Brown, R.; Shea, Steven.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 162, No. 3 I, 2000, p. 1004-1008.

Research output: Contribution to journalArticle

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