Hyperalimentation as cause of markedly worsened metabolic control in a patient with autoantibodies to the insulin receptor

David L. Vesely, Matthew J. Coleman, Peter O. Kohler, Richard M. Jordan, Sharilyn Stanley

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Patients with type B insulin resistance and acanthosis nigricans have autoantibodies to their insulin receptors and usually have signs and symptoms of other autoimmune diseases. The first case demonstrating that hyperalimentation markedly disturbs blood glucose control in type B insulin-resistant patients is described. Neither prednisone, insulin (up to 240 units per hour), nor tolbutamide appeared to help this patient's metabolic control. After the addition of cyclophosphamide for one week, the anti-insulin receptor auto-antibody titer dropped from greater than 1: 1,000 to 1: 1. Six months later, the patient had a complete remission, which is rare, with only three other reported remissions in these patients with type B insulin resistance.

Original languageEnglish (US)
Pages (from-to)504-508
Number of pages5
JournalThe American Journal of Medicine
Volume79
Issue number4
DOIs
StatePublished - Oct 1985

ASJC Scopus subject areas

  • Medicine(all)

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