Hydrocodone-acetaminophen for pain control in first-trimester surgical abortion: A randomized controlled trial

Elizabeth A. Micks, Alison Edelman, Regina Maria Renner, Rongwei (Rochelle) Fu, William Lambert, Paula Bednarek, Mark D. Nichols, Ethan H. Beckley, Jeffrey Jensen

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Objective: Although hydrocodone-acetaminophen is commonly used for pain control in first-trimester abortion, the efficacy of oral opioids for decreasing pain has not been established. Our objective was to estimate the effect of hydrocodone-acetaminophen on patient pain perception during first-trimester surgical abortion. Methods: We conducted a randomized, double-blinded, placebo-controlled trial. Patients (before 11 weeks of gestation) received standard premedication (ibuprofen and lorazepam) and a paracervical block with the addition of 10 mg hydrocodone and 650 mg acetaminophen or placebo 45-90 minutes before surgical abortion. A sample size of 120 was calculated to provide 80% power to show a 15-mm difference (α=0.05) in the primary outcome of pain with uterine aspiration (100-mm visual analog scale). Secondary outcomes were pain at additional time points, satisfaction, side effects, adverse events, and need for additional pain medications. Results: There were no significant differences in demographics or baseline pain between groups. There were no differences in pain scores between patients receiving hydrocodone-acetaminophen compared with placebo during uterine aspiration (65.7 mm compared with 63.2 mm, P=.59) or other procedural time points. There were no differences in satisfaction or need for additional pain medications. Patients who received hydrocodone-acetaminophen had more postoperative nausea than those receiving placebo (P=.03) when controlling for baseline nausea. No medication-related adverse events were noted. Conclusion: Hydrocodone-acetaminophen does not decrease pain during first-trimester abortion and may increase postoperative nausea. Clinical Trial Registration: Clinicaltrials.gov, www.clinicaltrials.gov, NCT01330459.

Original languageEnglish (US)
Pages (from-to)1060-1069
Number of pages10
JournalObstetrics and Gynecology
Volume120
Issue number5
DOIs
Publication statusPublished - Nov 2012

    Fingerprint

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this