Hybrid mice as genetic models of high alcohol consumption

Y. A. Blednov, Angela Ozburn, D. Walker, S. Ahmed, John Belknap, R. A. Harris

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

We showed that F1 hybrid genotypes may provide a broader variety of ethanol drinking phenotypes than the inbred progenitor strains used to create the hybrids (Blednov et al. in Alcohol Clin Exp Res 29:1949-1958, 2005). To extend this work, we characterized alcohol consumption as well as intake of other tastants (saccharin, quinine and sodium chloride) in five inbred strains of mice (FVB, SJL, B6, BUB, NZB) and in their reciprocal F1 hybrids with B6 (FVBxB6; B6xFVB; NZBxB6; B6xNZB; BUBxB6; B6xBUB; SJLxB6; B6xSJL). We also compared ethanol intake in these mice for several concentrations before and after two periods of abstinence. F1 hybrid mice derived from the crosses of B6 and FVB and also B6 and SJL drank higher levels of ethanol than their progenitor strains, demonstrating overdominance for two-bottle choice drinking test. The B6 and NZB hybrid showed additivity in two-bottle choice drinking, whereas the hybrid of B6 and BUB demonstrated full or complete dominance. Genealogical origin, as well as non-alcohol taste preferences (sodium chloride), predicted ethanol consumption. Mice derived from the crosses of B6 and FVB showed high sustained alcohol preference and the B6 and NZB hybrids showed reduced alcohol preference after periods of abstinence. These new genetic models offer some advantages over inbred strains because they provide high, sustained, alcohol intake, and should allow mapping of loci important for the genetic architecture of these traits.

Original languageEnglish (US)
Pages (from-to)93-110
Number of pages18
JournalBehavior Genetics
Volume40
Issue number1
DOIs
StatePublished - Jan 2010

Fingerprint

Genetic Models
Alcohol Drinking
alcohol
mice
Ethanol
Alcohols
ethanol
Drinking
drinking
alcohols
Sodium Chloride
sodium chloride
bottles
Saccharin
quinine
Inbred Strains Mice
Genetic Loci
Quinine
saccharin
overdominance

Keywords

  • Alcohol intake
  • F1 hybrid
  • Inbred strains
  • Overdominance
  • Tastes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Ecology, Evolution, Behavior and Systematics

Cite this

Blednov, Y. A., Ozburn, A., Walker, D., Ahmed, S., Belknap, J., & Harris, R. A. (2010). Hybrid mice as genetic models of high alcohol consumption. Behavior Genetics, 40(1), 93-110. https://doi.org/10.1007/s10519-009-9298-4

Hybrid mice as genetic models of high alcohol consumption. / Blednov, Y. A.; Ozburn, Angela; Walker, D.; Ahmed, S.; Belknap, John; Harris, R. A.

In: Behavior Genetics, Vol. 40, No. 1, 01.2010, p. 93-110.

Research output: Contribution to journalArticle

Blednov, YA, Ozburn, A, Walker, D, Ahmed, S, Belknap, J & Harris, RA 2010, 'Hybrid mice as genetic models of high alcohol consumption', Behavior Genetics, vol. 40, no. 1, pp. 93-110. https://doi.org/10.1007/s10519-009-9298-4
Blednov, Y. A. ; Ozburn, Angela ; Walker, D. ; Ahmed, S. ; Belknap, John ; Harris, R. A. / Hybrid mice as genetic models of high alcohol consumption. In: Behavior Genetics. 2010 ; Vol. 40, No. 1. pp. 93-110.
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