Hybrid FDG-PET/MR compared to FDG-PET/CT in adult lymphoma patients

Wendy Atkinson, Ciprian Catana, Jeremy S. Abramson, Grae Arabasz, Shanaugh McDermott, Onofrio Catalano, Victorine Muse, Michael A. Blake, Jeffrey Barnes, Martin Shelly, Ephraim Hochberg, Bruce R. Rosen, Alexander Guimaraes

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Purpose: The goal of this study is to evaluate the diagnostic performance of simultaneous FDG-PET/MR including diffusion compared to FDG-PET/CT in patients with lymphoma. Methods: Eighteen patients with a confirmed diagnosis of non-Hodgkin’s (NHL) or Hodgkin’s lymphoma (HL) underwent an IRB-approved, single-injection/dual-imaging protocol consisting of a clinical FDG-PET/CT and subsequent FDG-PET/MR scan. PET images from both modalities were reconstructed iteratively. Attenuation correction was performed using low-dose CT data for PET/CT and Dixon-MR sequences for PET/MR. Diffusion-weighted imaging was performed. SUVmax was measured and compared between modalities and the apparent diffusion coefficient (ADC) using ROI analysis by an experienced radiologist using OsiriX. Strength of correlation between variables was measured using the Pearson correlation coefficient (rp). Results: Of the 18 patients included in this study, 5 had HL and 13 had NHL. The median age was 51 ± 14.8 years. Sixty-five FDG-avid lesions were identified. All FDG-avid lesions were visible with comparable contrast, and therefore initial and follow-up staging was identical between both examinations. SUVmax from FDG-PET/MR [(mean ± sem) (21.3 ± 2.07)] vs. FDG-PET/CT (mean 23.2 ± 2.8) demonstrated a strongly positive correlation [rs = 0.95 (0.94, 0.99); p min and SUVmax from FDG-PET/MR [r = 0.17(−0.07, 0.66); p = 0.09]. Conclusion: FDG-PET/MR offers an equivalent whole-body staging examination as compared with PET/CT with an improved radiation safety profile in lymphoma patients. Correlation of ADC to SUVmax was weak, understating their lack of equivalence, but not undermining their potential synergy and differing importance.

Original languageEnglish (US)
Pages (from-to)1338-1348
Number of pages11
JournalAbdominal Radiology
Volume41
Issue number7
DOIs
StatePublished - Jul 1 2016

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Lymphoma
Hodgkin Disease
Research Ethics Committees
Positron-Emission Tomography
Non-Hodgkin's Lymphoma
Radiation
Safety
Injections

Keywords

  • Diffusion-weighted imaging
  • FDG
  • Lymphoma
  • PET/MRI
  • SUV

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology
  • Urology
  • Radiological and Ultrasound Technology

Cite this

Atkinson, W., Catana, C., Abramson, J. S., Arabasz, G., McDermott, S., Catalano, O., ... Guimaraes, A. (2016). Hybrid FDG-PET/MR compared to FDG-PET/CT in adult lymphoma patients. Abdominal Radiology, 41(7), 1338-1348. https://doi.org/10.1007/s00261-016-0638-6

Hybrid FDG-PET/MR compared to FDG-PET/CT in adult lymphoma patients. / Atkinson, Wendy; Catana, Ciprian; Abramson, Jeremy S.; Arabasz, Grae; McDermott, Shanaugh; Catalano, Onofrio; Muse, Victorine; Blake, Michael A.; Barnes, Jeffrey; Shelly, Martin; Hochberg, Ephraim; Rosen, Bruce R.; Guimaraes, Alexander.

In: Abdominal Radiology, Vol. 41, No. 7, 01.07.2016, p. 1338-1348.

Research output: Contribution to journalArticle

Atkinson, W, Catana, C, Abramson, JS, Arabasz, G, McDermott, S, Catalano, O, Muse, V, Blake, MA, Barnes, J, Shelly, M, Hochberg, E, Rosen, BR & Guimaraes, A 2016, 'Hybrid FDG-PET/MR compared to FDG-PET/CT in adult lymphoma patients', Abdominal Radiology, vol. 41, no. 7, pp. 1338-1348. https://doi.org/10.1007/s00261-016-0638-6
Atkinson W, Catana C, Abramson JS, Arabasz G, McDermott S, Catalano O et al. Hybrid FDG-PET/MR compared to FDG-PET/CT in adult lymphoma patients. Abdominal Radiology. 2016 Jul 1;41(7):1338-1348. https://doi.org/10.1007/s00261-016-0638-6
Atkinson, Wendy ; Catana, Ciprian ; Abramson, Jeremy S. ; Arabasz, Grae ; McDermott, Shanaugh ; Catalano, Onofrio ; Muse, Victorine ; Blake, Michael A. ; Barnes, Jeffrey ; Shelly, Martin ; Hochberg, Ephraim ; Rosen, Bruce R. ; Guimaraes, Alexander. / Hybrid FDG-PET/MR compared to FDG-PET/CT in adult lymphoma patients. In: Abdominal Radiology. 2016 ; Vol. 41, No. 7. pp. 1338-1348.
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AU - Catalano, Onofrio

AU - Muse, Victorine

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