Humoral immunity due to long-lived plasma cells

Mark K. Slifka, Rustom Antia, Jason K. Whitmire, Rafi Ahmed

    Research output: Contribution to journalArticle

    828 Scopus citations

    Abstract

    Conventional models suggest that long-term antibody responses are maintained by the continuous differentiation of memory B cells into antibody- secreting plasma cells. This is based on the notion that plasma cells are short-lived and need to be continually replenished by memory B cells. We examined the issue of plasma cell longevity by following the persistence of LCMV-specific antibody and plasma cell numbers after in vivo depletion of memory B cells and by adoptive transfer of virus-specific plasma cells into naive mice. The results show that a substantial fraction of plasma cells can survive and continue to secrete antibody for extended periods of time (>1 year) in the absence of any detectable memory B cells. This study documents the existence of long-lived plasma cells and demonstrates a new mechanism by which humoral immunity is maintained.

    Original languageEnglish (US)
    Pages (from-to)363-372
    Number of pages10
    JournalImmunity
    Volume8
    Issue number3
    DOIs
    StatePublished - Mar 1998

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology
    • Infectious Diseases

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