Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets

Luca Cassetta, Stamatina Fragkogianni, Andrew H. Sims, Agnieszka Swierczak, Lesley M. Forrester, Hui Zhang, Daniel Y.H. Soong, Tiziana Cotechini, Pavana Anur, Elaine Lin, Antonella Fidanza, Martha Lopez-Yrigoyen, Michael R. Millar, Alexandra Urman, Zhichao Ai, Paul Spellman, E. Shelley Hwang, J. Michael Dixon, Lisa Wiechmann, Lisa Coussens & 2 others Harriet O. Smith, Jeffrey W. Pollard

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Cassetta et al. identify a breast cancer tumor-associated macrophage (TAM) transcriptome that is different from those of monocytes and tissue-resident macrophages, and which is associated with shorter disease-specific survival, and they demonstrate crosstalk between tumor cells and TAMs via SIGLEC1, CCL8, and CSF1.

Original languageEnglish (US)
Pages (from-to)588-602.e10
JournalCancer Cell
Volume35
Issue number4
DOIs
StatePublished - Apr 15 2019

Fingerprint

Monocytes
Biomarkers
Macrophages
Breast Neoplasms
Transcriptome
Neoplasms
Survival
Therapeutics

Keywords

  • breast cancer
  • CCL8
  • endometrial cancer
  • human circulating monocytes
  • human macrophages
  • SIGLEC1
  • tumor microenvironment

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

Cite this

Cassetta, L., Fragkogianni, S., Sims, A. H., Swierczak, A., Forrester, L. M., Zhang, H., ... Pollard, J. W. (2019). Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets. Cancer Cell, 35(4), 588-602.e10. https://doi.org/10.1016/j.ccell.2019.02.009

Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets. / Cassetta, Luca; Fragkogianni, Stamatina; Sims, Andrew H.; Swierczak, Agnieszka; Forrester, Lesley M.; Zhang, Hui; Soong, Daniel Y.H.; Cotechini, Tiziana; Anur, Pavana; Lin, Elaine; Fidanza, Antonella; Lopez-Yrigoyen, Martha; Millar, Michael R.; Urman, Alexandra; Ai, Zhichao; Spellman, Paul; Hwang, E. Shelley; Dixon, J. Michael; Wiechmann, Lisa; Coussens, Lisa; Smith, Harriet O.; Pollard, Jeffrey W.

In: Cancer Cell, Vol. 35, No. 4, 15.04.2019, p. 588-602.e10.

Research output: Contribution to journalArticle

Cassetta, L, Fragkogianni, S, Sims, AH, Swierczak, A, Forrester, LM, Zhang, H, Soong, DYH, Cotechini, T, Anur, P, Lin, E, Fidanza, A, Lopez-Yrigoyen, M, Millar, MR, Urman, A, Ai, Z, Spellman, P, Hwang, ES, Dixon, JM, Wiechmann, L, Coussens, L, Smith, HO & Pollard, JW 2019, 'Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets', Cancer Cell, vol. 35, no. 4, pp. 588-602.e10. https://doi.org/10.1016/j.ccell.2019.02.009
Cassetta, Luca ; Fragkogianni, Stamatina ; Sims, Andrew H. ; Swierczak, Agnieszka ; Forrester, Lesley M. ; Zhang, Hui ; Soong, Daniel Y.H. ; Cotechini, Tiziana ; Anur, Pavana ; Lin, Elaine ; Fidanza, Antonella ; Lopez-Yrigoyen, Martha ; Millar, Michael R. ; Urman, Alexandra ; Ai, Zhichao ; Spellman, Paul ; Hwang, E. Shelley ; Dixon, J. Michael ; Wiechmann, Lisa ; Coussens, Lisa ; Smith, Harriet O. ; Pollard, Jeffrey W. / Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets. In: Cancer Cell. 2019 ; Vol. 35, No. 4. pp. 588-602.e10.
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