Human striatum: the distribution of neurofibrillary tangles in Alzheimer's disease

N. Selden, M. M. Mesulam, C. Geula

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

The distribution of neurofibrillary tangles and senile plaques was surveyed in the striatum of Alzheimer's disease cases. Neurofibrillary tangles were present throughout the striatum, but displayerd significantly higher densities in the nucleus accumbens, olfactory tubercle and tail of the caudate nucleus. Senile plaques with dense amyloid cores showed a similar pattern of distribution. By contrast, non-cored senile plaques were homogenously distributed in all striatal territories. No tangles and few plaques were observed in the striatum of control cases. These findings suggest that the 'limbic' striatum is preferentially vulnerable to pathology in Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)327-331
Number of pages5
JournalBrain research
Volume648
Issue number2
DOIs
StatePublished - Jun 20 1994
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Limbic system
  • Plaque
  • Striatum
  • Tangle
  • Ventral straitum

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Fingerprint

Dive into the research topics of 'Human striatum: the distribution of neurofibrillary tangles in Alzheimer's disease'. Together they form a unique fingerprint.

Cite this