Human rhinovirus 14 complexed with antiviral compound R 61837

Michael S. Chapman, Iwona Minor, Michael G. Rossmann, Guy D. Diana, Koen Andries

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

The binding of the antirhinoviral agent R 61837 to human rhinovirus 14 has been examined by X-ray crystallographic methods. The compound R 61837 binds in the same pocket (underneath the canyon floor) as the "WIN" antirhinoviral agents. It does not penetrate as far into the pocket but causes similar conformational changes in the virus capsid. The movement of residues 1217 to 1221 of viral protein 1 (in the "FMDV loop") is more pronounced for R 61837 than for WIN compounds. Although both R 61837 and WIN antiviral agents partially fill the same hydrophobic pocket, atomic binding interactions differ, showing that considerable diversity in the nature of antiviral agents is possible.

Original languageEnglish (US)
Pages (from-to)455-463
Number of pages9
JournalJournal of molecular biology
Volume217
Issue number3
DOIs
StatePublished - Feb 5 1991

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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