Abstract
Type I interferons (IFN) are important regulators of both innate and acquired immunity. We have used an in vitro system of human CD4+. T cell differentiation to determine how IFN-β influences development of T helper (Th) subsets and homing receptor expression. IFN-β promoted differentiation of CD4+. T cells that produce low levels of both IFN-γ and lymphotoxin compared to interleukin (IL)-12-derived Th1 CD4+ T cells. IFN-β inhibited production of Th2 cytokines (IL-5 and IL-13) and augmented IL-12-mediated IL-10 secretion. In addition. IFN-β significantly enhanced L-selectin expression on CD4+ T cells and synergized with IL-12 to induce expression of cutaneous lymphocyte-associated antigen (CLA). This Th1 L-selectin+, CLA+ phenotype is characteristic of T cells found in normal human skin and suggests a role for type T IFN in the regulation of Th subset differentiation and tissue-specific homing receptors.
Original language | English (US) |
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Pages (from-to) | 2650-2656 |
Number of pages | 7 |
Journal | European Journal of Immunology |
Volume | 27 |
Issue number | 10 |
DOIs | |
State | Published - Oct 1997 |
Externally published | Yes |
Keywords
- Cytokine
- Homing
- Human
- Interferon-β
- T lymphocyte
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology