Human neurobehavioral research methods: Impact of subject variables

Wyndham Anger, O. J. Sizemore, S. J. Grossmann, J. A. Glasser, R. Letz, R. Bowler

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Behavioral tests are used in work site and community research to detect and characterize the effects of neurotoxic chemical exposures in human populations, but the influence of subject variables on test performance has not been well studied in normal adult populations. This research sought to evaluate the impact of two variables, education and cultural group, on 18 widely used tests of neurotoxic insult. Behavioral tests from the two consensus neurotoxicity test batteries (established by the World Health Organization and the U.S. Agency for Toxic Substances and Disease Registry) were administered to 715 people aged 26-45 with 0-18 years of education, drawn from European descent United States majority, American Indian, African American, and Latin American populations. Education, cultural group, age, and gender affected the outcome of behavioral tests as revealed by ANOVA, MANOVA, and multiple regression techniques. Education, followed by cultural group, accounted for the most variance in the tests studied. More importantly, years of education and cultural group had 13-25% shared variance on the cognitive tests and highly significant interactions derived from ANOVA tests. This suggests that these factors should be controlled in the design of a study rather than in the statistical analysis. Because these factors can mimic a neurotoxic insult, failure to adequately control and analyze them could lead to inaccurate conclusions about the association between poor performance and neurotoxic insult.

Original languageEnglish (US)
Pages (from-to)18-41
Number of pages24
JournalEnvironmental Research
Volume73
Issue number1-2
DOIs
StatePublished - Apr 1997

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research method
Education
Research
Analysis of variance (ANOVA)
education
Analysis of Variance
Population
North American Indians
Poisons
Workplace
African Americans
Registries
Consensus
Statistical methods
Age Groups
test
Health
African American
toxic substance
World Health Organization

ASJC Scopus subject areas

  • Environmental Science(all)

Cite this

Anger, W., Sizemore, O. J., Grossmann, S. J., Glasser, J. A., Letz, R., & Bowler, R. (1997). Human neurobehavioral research methods: Impact of subject variables. Environmental Research, 73(1-2), 18-41. https://doi.org/10.1006/enrs.1997.3707

Human neurobehavioral research methods : Impact of subject variables. / Anger, Wyndham; Sizemore, O. J.; Grossmann, S. J.; Glasser, J. A.; Letz, R.; Bowler, R.

In: Environmental Research, Vol. 73, No. 1-2, 04.1997, p. 18-41.

Research output: Contribution to journalArticle

Anger, W, Sizemore, OJ, Grossmann, SJ, Glasser, JA, Letz, R & Bowler, R 1997, 'Human neurobehavioral research methods: Impact of subject variables', Environmental Research, vol. 73, no. 1-2, pp. 18-41. https://doi.org/10.1006/enrs.1997.3707
Anger, Wyndham ; Sizemore, O. J. ; Grossmann, S. J. ; Glasser, J. A. ; Letz, R. ; Bowler, R. / Human neurobehavioral research methods : Impact of subject variables. In: Environmental Research. 1997 ; Vol. 73, No. 1-2. pp. 18-41.
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