Human Melatonin Production Decreases With Age

Robert L. Sack; Alfred J. Lewy; Danielle L. Erb; William M. Vollmer; Clifford M. Singer

doi:10.1111/j.1600-079X.1986.tb00760.x

Human Melatonin Production Decreases With Age

Robert L. Sack, Alfred J. Lewy, Danielle L. Erb, William M. Vollmer, Clifford M. Singer

Pediatrics

Research output: Contribution to journal › Article › peer-review

382 Scopus citations

Abstract

The purpose of this study was to investigate the effects of time of year and demographic variables on the amplitude of melatonin production in normal human subjects. Melatonin production was estimated by measuring the overnight excretion of its major urinary metabolite, 6‐hydroxymelatonin. Urine was collected on three consecutive nights in the summer from a sample of 60 normal subjects balanced for sex and age. The collections were repeated in a subgroup during the winter. Melatonin production clearly declined with age but was not influenced by other demographic variables or by season of the year.

Original language	English (US)
Pages (from-to)	379-388
Number of pages	10
Journal	Journal of pineal research
Volume	3
Issue number	4
DOIs	https://doi.org/10.1111/j.1600-079X.1986.tb00760.x
State	Published - Oct 1986

Keywords

6‐hydroxymelatonin
aging
demographic variables
pineal gland
seasonal rhythms

ASJC Scopus subject areas

Endocrinology

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10.1111/j.1600-079X.1986.tb00760.x

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title = "Human Melatonin Production Decreases With Age",

abstract = "The purpose of this study was to investigate the effects of time of year and demographic variables on the amplitude of melatonin production in normal human subjects. Melatonin production was estimated by measuring the overnight excretion of its major urinary metabolite, 6‐hydroxymelatonin. Urine was collected on three consecutive nights in the summer from a sample of 60 normal subjects balanced for sex and age. The collections were repeated in a subgroup during the winter. Melatonin production clearly declined with age but was not influenced by other demographic variables or by season of the year.",

keywords = "6‐hydroxymelatonin, aging, demographic variables, pineal gland, seasonal rhythms",

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AU - Sack, Robert L.

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AU - Vollmer, William M.

AU - Singer, Clifford M.

PY - 1986/10

Y1 - 1986/10

N2 - The purpose of this study was to investigate the effects of time of year and demographic variables on the amplitude of melatonin production in normal human subjects. Melatonin production was estimated by measuring the overnight excretion of its major urinary metabolite, 6‐hydroxymelatonin. Urine was collected on three consecutive nights in the summer from a sample of 60 normal subjects balanced for sex and age. The collections were repeated in a subgroup during the winter. Melatonin production clearly declined with age but was not influenced by other demographic variables or by season of the year.

AB - The purpose of this study was to investigate the effects of time of year and demographic variables on the amplitude of melatonin production in normal human subjects. Melatonin production was estimated by measuring the overnight excretion of its major urinary metabolite, 6‐hydroxymelatonin. Urine was collected on three consecutive nights in the summer from a sample of 60 normal subjects balanced for sex and age. The collections were repeated in a subgroup during the winter. Melatonin production clearly declined with age but was not influenced by other demographic variables or by season of the year.

KW - 6‐hydroxymelatonin

KW - aging

KW - demographic variables

KW - pineal gland

KW - seasonal rhythms

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Human Melatonin Production Decreases With Age

Abstract

Keywords

ASJC Scopus subject areas

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