Human innate Mycobacterium tuberculosis-reactive αβTCR + thymocytes

Marielle Gold, Heather D. Ehlinger, Matthew S. Cook, Susan K. Smyk-Pearson, Paul T. Wille, Ross M. Ungerleider, Deborah Lewinsohn, David Lewinsohn

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The control of Mycobacterium tuberculosis (Mtb) infection is heavily dependent on the adaptive Th1 cellular immune response. Paradoxically, optimal priming of the Th1 response requires activation of priming dendritic cells with Th1 cytokine IFN-γ. At present, the innate cellular mechanisms required for the generation of an optimal Th1 T cell response remain poorly characterized. We hypothesized that innate Mtb-reactive T cells provide an early source of IFN-γ to fully activate Mtb-exposed dendritic cells. Here, we report the identification of a novel population of Mtb-reactive CD4- αβTCR+ innate thymocytes. These cells are present at high frequencies, respond to Mtb-infected cells by producing IFN-γ directly ex vivo, and display characteristics of effector memory T cells. This novel innate population of Mtb-reactive T cells will drive further investigation into the role of these cells in the containment of Mtb following infectious exposure. Furthermore, this is the first demonstration of a human innate pathogen-specific αβTCR+ T cell and is likely to inspire further investigation into innate T cells recognizing other important human pathogens.

Original languageEnglish (US)
JournalPLoS Pathogens
Volume4
Issue number2
DOIs
StatePublished - Feb 2008

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Thymocytes
Mycobacterium tuberculosis
T-Lymphocytes
Dendritic Cells
Th1 Cells
Mycobacterium Infections
Cellular Immunity
Population
Cytokines

ASJC Scopus subject areas

  • Microbiology
  • Parasitology
  • Virology
  • Immunology
  • Genetics
  • Molecular Biology

Cite this

Gold, M., Ehlinger, H. D., Cook, M. S., Smyk-Pearson, S. K., Wille, P. T., Ungerleider, R. M., ... Lewinsohn, D. (2008). Human innate Mycobacterium tuberculosis-reactive αβTCR + thymocytes. PLoS Pathogens, 4(2). https://doi.org/10.1371/journal.ppat.0040039

Human innate Mycobacterium tuberculosis-reactive αβTCR + thymocytes. / Gold, Marielle; Ehlinger, Heather D.; Cook, Matthew S.; Smyk-Pearson, Susan K.; Wille, Paul T.; Ungerleider, Ross M.; Lewinsohn, Deborah; Lewinsohn, David.

In: PLoS Pathogens, Vol. 4, No. 2, 02.2008.

Research output: Contribution to journalArticle

Gold, M, Ehlinger, HD, Cook, MS, Smyk-Pearson, SK, Wille, PT, Ungerleider, RM, Lewinsohn, D & Lewinsohn, D 2008, 'Human innate Mycobacterium tuberculosis-reactive αβTCR + thymocytes', PLoS Pathogens, vol. 4, no. 2. https://doi.org/10.1371/journal.ppat.0040039
Gold M, Ehlinger HD, Cook MS, Smyk-Pearson SK, Wille PT, Ungerleider RM et al. Human innate Mycobacterium tuberculosis-reactive αβTCR + thymocytes. PLoS Pathogens. 2008 Feb;4(2). https://doi.org/10.1371/journal.ppat.0040039
Gold, Marielle ; Ehlinger, Heather D. ; Cook, Matthew S. ; Smyk-Pearson, Susan K. ; Wille, Paul T. ; Ungerleider, Ross M. ; Lewinsohn, Deborah ; Lewinsohn, David. / Human innate Mycobacterium tuberculosis-reactive αβTCR + thymocytes. In: PLoS Pathogens. 2008 ; Vol. 4, No. 2.
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