TY - JOUR
T1 - Human immunodeficiency virus (HIV)-specific antibody in cervicovaginal lavage specimens obtained from women infected with HIV type 1
AU - Williams, Selvi B.
AU - Flanigan, Timothy P.
AU - Cu-Uvin, Susan
AU - Mayer, Kenneth
AU - Williams, Pepper
AU - Ettore, Christopher A.
AU - Artenstein, Andrew W.
AU - Duerr, Ann
AU - VanCott, Thomas C.
N1 - Funding Information:
Financial support: Centers for Disease Control and Prevention (HIV Epidemiology Research Study grant U64/CCU 106795) and National Institutes of Health–National Institute of Allergy and Infectious Diseases (grants P30-AI42853, RO1 35543-02, and RO1 AI40350). This work was supported in part by Cooperative Agreement no. DAMD17-93-V-3004 between the US Army Medical Research and Material Command and the Henry M. Jackson Foundation for the Advancement of Military Medicine.
PY - 2002/9/1
Y1 - 2002/9/1
N2 - To evaluate correlates of anti-human immunodeficiency virus (HIV) type 1 (HIV-1) immunoglobulin (Ig) in the genital tract, anti-HIV-gp120 IgA and IgG titers in cervicovaginal lavage specimens obtained from 104 HIV-1-infected women were measured by enzyme-linked immunosorbent assay. Overall, 24% and 94% of women had detectable anti-gp120 IgA and IgG, respectively. CD4 cell count correlated negatively with total IgA concentration (r = -0.301; P = .0027) and positively with specific IgA activity (anti-gp120 IgA titer/total IgA concentration, r = 0.306; P - .0023). Women with bacterial vaginosis had 5-fold lower anti-gp120 IgG titer (P = .0042), 5-fold lower total IgG concentration (P ≤ .0001), and 4-fold higher specific IgG activity (P = .0474) compared with women who did not have bacterial vaginosis. Enhanced understanding of correlates of mucosal immunity to HIV-1 may assist in the design of vaccine strategies or in the prevention of vertical transmission of HIV-1.
AB - To evaluate correlates of anti-human immunodeficiency virus (HIV) type 1 (HIV-1) immunoglobulin (Ig) in the genital tract, anti-HIV-gp120 IgA and IgG titers in cervicovaginal lavage specimens obtained from 104 HIV-1-infected women were measured by enzyme-linked immunosorbent assay. Overall, 24% and 94% of women had detectable anti-gp120 IgA and IgG, respectively. CD4 cell count correlated negatively with total IgA concentration (r = -0.301; P = .0027) and positively with specific IgA activity (anti-gp120 IgA titer/total IgA concentration, r = 0.306; P - .0023). Women with bacterial vaginosis had 5-fold lower anti-gp120 IgG titer (P = .0042), 5-fold lower total IgG concentration (P ≤ .0001), and 4-fold higher specific IgG activity (P = .0474) compared with women who did not have bacterial vaginosis. Enhanced understanding of correlates of mucosal immunity to HIV-1 may assist in the design of vaccine strategies or in the prevention of vertical transmission of HIV-1.
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U2 - 10.1086/342201
DO - 10.1086/342201
M3 - Article
C2 - 12173138
AN - SCOPUS:0036720455
SN - 1058-4838
VL - 35
SP - 611
EP - 617
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 5
ER -