Human fibroblast interferon gene lacks introns

Richard M. Lawn, John Adelman, Arthur E. Franke, Catherine M. Houck, Mitchell Gross, Richard Najarian, David V. Goeddel

Research output: Contribution to journalArticle

69 Scopus citations


A recombinant λ bacteriophage isolated from a human genome library contains the gene for fibroblast interferon (IFN-β1). The DNA sequence of this gene is identical to the sequence of its mRNA and is devoid of introns.

Original languageEnglish (US)
Pages (from-to)1045-1052
Number of pages8
JournalNucleic acids research
Issue number5
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • Genetics

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    Lawn, R. M., Adelman, J., Franke, A. E., Houck, C. M., Gross, M., Najarian, R., & Goeddel, D. V. (1981). Human fibroblast interferon gene lacks introns. Nucleic acids research, 9(5), 1045-1052.