Human fibroblast interferon gene lacks introns

Richard M. Lawn, John Adelman, Arthur E. Franke, Catherine M. Houck, Mitchell Gross, Richard Najarian, David V. Goeddel

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

A recombinant λ bacteriophage isolated from a human genome library contains the gene for fibroblast interferon (IFN-β1). The DNA sequence of this gene is identical to the sequence of its mRNA and is devoid of introns.

Original languageEnglish (US)
Pages (from-to)1045-1052
Number of pages8
JournalNucleic Acids Research
Volume9
Issue number5
DOIs
StatePublished - Mar 11 1981
Externally publishedYes

Fingerprint

Interferons
Fibroblasts
Interferon-beta
Introns
Genes
Gene
Bacteriophages
Genomic Library
DNA sequences
Human Genome
DNA Sequence
Messenger RNA
Genome
Human
Libraries
Recombinant

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Health, Toxicology and Mutagenesis
  • Toxicology
  • Genetics(clinical)
  • Genetics

Cite this

Lawn, R. M., Adelman, J., Franke, A. E., Houck, C. M., Gross, M., Najarian, R., & Goeddel, D. V. (1981). Human fibroblast interferon gene lacks introns. Nucleic Acids Research, 9(5), 1045-1052. https://doi.org/10.1093/nar/9.5.1045

Human fibroblast interferon gene lacks introns. / Lawn, Richard M.; Adelman, John; Franke, Arthur E.; Houck, Catherine M.; Gross, Mitchell; Najarian, Richard; Goeddel, David V.

In: Nucleic Acids Research, Vol. 9, No. 5, 11.03.1981, p. 1045-1052.

Research output: Contribution to journalArticle

Lawn, RM, Adelman, J, Franke, AE, Houck, CM, Gross, M, Najarian, R & Goeddel, DV 1981, 'Human fibroblast interferon gene lacks introns', Nucleic Acids Research, vol. 9, no. 5, pp. 1045-1052. https://doi.org/10.1093/nar/9.5.1045
Lawn RM, Adelman J, Franke AE, Houck CM, Gross M, Najarian R et al. Human fibroblast interferon gene lacks introns. Nucleic Acids Research. 1981 Mar 11;9(5):1045-1052. https://doi.org/10.1093/nar/9.5.1045
Lawn, Richard M. ; Adelman, John ; Franke, Arthur E. ; Houck, Catherine M. ; Gross, Mitchell ; Najarian, Richard ; Goeddel, David V. / Human fibroblast interferon gene lacks introns. In: Nucleic Acids Research. 1981 ; Vol. 9, No. 5. pp. 1045-1052.
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