Human Cytomegalovirus Stimulates Cellular IKK2 Activity and Requires the Enzyme for Productive Replication

Patrizia Caposio, Michel Dreano, Gianni Garotta, Giorgio Gribaudo, Santo Landolfo

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Human cytomegalovirus (HCMV) exploits the host transcription factor NF-κB to enhance its own replication, dissemination, and reactivation from latency. Here we report that HCMV infection activates the upstream IκB kinase (IKK) complex and that its catalytic IKK2 subunit is required for HCMV-induced NF-κB activation, as well as the replication of different HCMV strains. These results indicate that IKK2 is essential for HCMV replication and emphasize the feasibility of blocking NF-κB activation as a way of inhibiting infection.

Original languageEnglish (US)
Pages (from-to)3190-3195
Number of pages6
JournalJournal of Virology
Volume78
Issue number6
DOIs
StatePublished - Mar 2004
Externally publishedYes

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Human herpesvirus 5
Cytomegalovirus
Enzymes
enzymes
IKappaB kinase
Cytomegalovirus Infections
protein subunits
Catalytic Domain
phosphotransferases (kinases)
Transcription Factors
Phosphotransferases
transcription factors
Infection
infection

ASJC Scopus subject areas

  • Immunology

Cite this

Human Cytomegalovirus Stimulates Cellular IKK2 Activity and Requires the Enzyme for Productive Replication. / Caposio, Patrizia; Dreano, Michel; Garotta, Gianni; Gribaudo, Giorgio; Landolfo, Santo.

In: Journal of Virology, Vol. 78, No. 6, 03.2004, p. 3190-3195.

Research output: Contribution to journalArticle

Caposio, Patrizia ; Dreano, Michel ; Garotta, Gianni ; Gribaudo, Giorgio ; Landolfo, Santo. / Human Cytomegalovirus Stimulates Cellular IKK2 Activity and Requires the Enzyme for Productive Replication. In: Journal of Virology. 2004 ; Vol. 78, No. 6. pp. 3190-3195.
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