Human cytomegalovirus latency and reactivation - A delicate balance between the virus and its host's immune system

Cecilia Söderberg-Nauclér, Jay A. Nelson

Research output: Contribution to journalArticle

79 Scopus citations

Abstract

Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus that still causes severe morbidity and mortality in immunocompromised individuals. During its evolution, the virus has developed sophisticated methods to evade immune recognition and to establish life-long persistence in its host. Today, we know that the virus establishes latency in myeloid lineage cells and that the virus is dependent on immune activation mechanisms to reactivate it from latency to produce a new viral progeny. During this process, a number of viral proteins are produced that interfere with different immune recognition pathways. The current knowledge of the delicate balance between the virus' continuous existence and its host's immune system will be summarized in this chapter. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish (US)
Pages (from-to)314-321
Number of pages8
JournalIntervirology
Volume42
Issue number5-6
DOIs
StatePublished - Feb 2000

Keywords

  • Allogeneic stimulation
  • Cytomegalovirus
  • Latency
  • Macrophages
  • Reactivation

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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