Human Cytomegalovirus Host Interactions: EGFR and Host Cell Signaling Is a Point of Convergence Between Viral Infection and Functional Changes in Infected Cells

Byeong Jae Lee, Chan Ki Min, Meaghan Hancock, Daniel N. Streblow, Patrizia Caposio, Felicia D. Goodrum, Andrew D. Yurochko

Research output: Contribution to journalReview articlepeer-review

Abstract

Viruses have evolved diverse strategies to manipulate cellular signaling pathways in order to promote infection and/or persistence. Human cytomegalovirus (HCMV) possesses a number of unique properties that allow the virus to alter cellular events required for infection of a diverse array of host cell types and long-term persistence. Of specific importance is infection of bone marrow derived and myeloid lineage cells, such as peripheral blood monocytes and CD34+ hematopoietic progenitor cells (HPCs) because of their essential role in dissemination of the virus and for the establishment of latency. Viral induced signaling through the Epidermal Growth Factor Receptor (EGFR) and other receptors such as integrins are key control points for viral-induced cellular changes and productive and latent infection in host organ systems. This review will explore the current understanding of HCMV strategies utilized to hijack cellular signaling pathways, such as EGFR, to promote the wide-spread dissemination and the classic life-long herpesvirus persistence.

Original languageEnglish (US)
Article number660901
JournalFrontiers in Microbiology
Volume12
DOIs
StatePublished - May 7 2021

Keywords

  • cell signaling
  • differentiation
  • epidermal growth factor receptor (EGFR)
  • glycoproteins
  • human cytomegalovirus (HCMV)
  • latency
  • monocytes
  • progenitor cells

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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