Human cytomegalovirus entry into cells

Adam L. Vanarsdall; David C. Johnson

doi:10.1016/j.coviro.2012.01.001

Human cytomegalovirus entry into cells

Adam L. Vanarsdall, David C. Johnson

Molecular Microbiology and Immunology

Research output: Contribution to journal › Review article › peer-review

127 Scopus citations

Abstract

Highlights: HCMV infect a broad spectrum of cells and entry into different cells involves different receptors, distinct pathways of entry, and the use of different gH/gL complexes: gH/gL and gH/gL/UL128-131. Entry into fibroblasts involves direct fusion with the plasma membrane whereas entry into epithelial and endothelial cells involves macropinocytosis followed by low pH-dependent fusion. The minimal fusion machinery is gB and gH/gL and these proteins will interact and fuse cells when expressed in apposing cell membranes. Previously described HCMV receptors characterized using lab strains do not describe gH/gL/UL128-131 dependent entry into epithelial and endothelial cells.

Original language	English (US)
Pages (from-to)	37-42
Number of pages	6
Journal	Current Opinion in Virology
Volume	2
Issue number	1
DOIs	https://doi.org/10.1016/j.coviro.2012.01.001
State	Published - Feb 2012

ASJC Scopus subject areas

Virology

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10.1016/j.coviro.2012.01.001

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title = "Human cytomegalovirus entry into cells",

abstract = "Highlights: HCMV infect a broad spectrum of cells and entry into different cells involves different receptors, distinct pathways of entry, and the use of different gH/gL complexes: gH/gL and gH/gL/UL128-131. Entry into fibroblasts involves direct fusion with the plasma membrane whereas entry into epithelial and endothelial cells involves macropinocytosis followed by low pH-dependent fusion. The minimal fusion machinery is gB and gH/gL and these proteins will interact and fuse cells when expressed in apposing cell membranes. Previously described HCMV receptors characterized using lab strains do not describe gH/gL/UL128-131 dependent entry into epithelial and endothelial cells.",

author = "Vanarsdall, {Adam L.} and Johnson, {David C.}",

note = "Funding Information: We thank Brent Ryckman and Paul Wille for critical reading of the review. Tiffani Howard designed and drew the cartoons. This work was supported by a grant from the National Institutes of Health , R01AI081517 to DCJ and a postdoctoral fellowship from the American Heart Association , 09POST2090081 to ALV.",

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AU - Johnson, David C.

N1 - Funding Information: We thank Brent Ryckman and Paul Wille for critical reading of the review. Tiffani Howard designed and drew the cartoons. This work was supported by a grant from the National Institutes of Health , R01AI081517 to DCJ and a postdoctoral fellowship from the American Heart Association , 09POST2090081 to ALV.

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N2 - Highlights: HCMV infect a broad spectrum of cells and entry into different cells involves different receptors, distinct pathways of entry, and the use of different gH/gL complexes: gH/gL and gH/gL/UL128-131. Entry into fibroblasts involves direct fusion with the plasma membrane whereas entry into epithelial and endothelial cells involves macropinocytosis followed by low pH-dependent fusion. The minimal fusion machinery is gB and gH/gL and these proteins will interact and fuse cells when expressed in apposing cell membranes. Previously described HCMV receptors characterized using lab strains do not describe gH/gL/UL128-131 dependent entry into epithelial and endothelial cells.

AB - Highlights: HCMV infect a broad spectrum of cells and entry into different cells involves different receptors, distinct pathways of entry, and the use of different gH/gL complexes: gH/gL and gH/gL/UL128-131. Entry into fibroblasts involves direct fusion with the plasma membrane whereas entry into epithelial and endothelial cells involves macropinocytosis followed by low pH-dependent fusion. The minimal fusion machinery is gB and gH/gL and these proteins will interact and fuse cells when expressed in apposing cell membranes. Previously described HCMV receptors characterized using lab strains do not describe gH/gL/UL128-131 dependent entry into epithelial and endothelial cells.

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Human cytomegalovirus entry into cells

Abstract

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