Abstract
Highlights: HCMV infect a broad spectrum of cells and entry into different cells involves different receptors, distinct pathways of entry, and the use of different gH/gL complexes: gH/gL and gH/gL/UL128-131. Entry into fibroblasts involves direct fusion with the plasma membrane whereas entry into epithelial and endothelial cells involves macropinocytosis followed by low pH-dependent fusion. The minimal fusion machinery is gB and gH/gL and these proteins will interact and fuse cells when expressed in apposing cell membranes. Previously described HCMV receptors characterized using lab strains do not describe gH/gL/UL128-131 dependent entry into epithelial and endothelial cells.
Original language | English (US) |
---|---|
Pages (from-to) | 37-42 |
Number of pages | 6 |
Journal | Current Opinion in Virology |
Volume | 2 |
Issue number | 1 |
DOIs | |
State | Published - Feb 2012 |
ASJC Scopus subject areas
- Virology