Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate

Giulio Draetta, Helen Piwnica-Worms, Deborah Morrison, Brian Druker, Thomas Roberts, David Beach

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178 Scopus citations

Abstract

cdc2 is a catalytic subunit of a protein kinase complex, called the M-phase promoting factor, that induces entry into mitosis and is universal among eukaryotes. In HeLa cells, cdc2 is shown to be the most abundant phosphotyrosine-containing protein and its phosphotyrosine content is subject to cell-cycle regulation. One site ofcdc2 tyrosine phosphorylation in vivo W selectively phosphorylated by pp60c-src in vitro.

Original languageEnglish (US)
Pages (from-to)738-744
Number of pages7
JournalNature
Volume336
Issue number6201
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

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    Draetta, G., Piwnica-Worms, H., Morrison, D., Druker, B., Roberts, T., & Beach, D. (1988). Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate. Nature, 336(6201), 738-744. https://doi.org/10.1038/336738a0