Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate

Giulio Draetta, Helen Piwnica-Worms, Deborah Morrison, Brian Druker, Thomas Roberts, David Beach

Research output: Contribution to journalArticle

176 Citations (Scopus)

Abstract

cdc2 is a catalytic subunit of a protein kinase complex, called the M-phase promoting factor, that induces entry into mitosis and is universal among eukaryotes. In HeLa cells, cdc2 is shown to be the most abundant phosphotyrosine-containing protein and its phosphotyrosine content is subject to cell-cycle regulation. One site ofcdc2 tyrosine phosphorylation in vivo W selectively phosphorylated by pp60c-src in vitro.

Original languageEnglish (US)
Pages (from-to)738-744
Number of pages7
JournalNature
Volume336
Issue number6201
StatePublished - 1988
Externally publishedYes

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CDC2 Protein Kinase
Phosphotyrosine
Protein-Tyrosine Kinases
Protein Kinases
Cell Cycle
Maturation-Promoting Factor
Eukaryota
HeLa Cells
Mitosis
Tyrosine
Catalytic Domain
Phosphorylation
Proteins
In Vitro Techniques

ASJC Scopus subject areas

  • General

Cite this

Draetta, G., Piwnica-Worms, H., Morrison, D., Druker, B., Roberts, T., & Beach, D. (1988). Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate. Nature, 336(6201), 738-744.

Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate. / Draetta, Giulio; Piwnica-Worms, Helen; Morrison, Deborah; Druker, Brian; Roberts, Thomas; Beach, David.

In: Nature, Vol. 336, No. 6201, 1988, p. 738-744.

Research output: Contribution to journalArticle

Draetta, G, Piwnica-Worms, H, Morrison, D, Druker, B, Roberts, T & Beach, D 1988, 'Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate', Nature, vol. 336, no. 6201, pp. 738-744.
Draetta G, Piwnica-Worms H, Morrison D, Druker B, Roberts T, Beach D. Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate. Nature. 1988;336(6201):738-744.
Draetta, Giulio ; Piwnica-Worms, Helen ; Morrison, Deborah ; Druker, Brian ; Roberts, Thomas ; Beach, David. / Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate. In: Nature. 1988 ; Vol. 336, No. 6201. pp. 738-744.
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