Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate

Giulio Draetta; Helen Piwnica-Worms; Deborah Morrison; Brian Druker; Thomas Roberts; David Beach

doi:10.1038/336738a0

Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate

Giulio Draetta, Helen Piwnica-Worms, Deborah Morrison, Brian Druker, Thomas Roberts, David Beach

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235 Scopus citations

Abstract

cdc2 is a catalytic subunit of a protein kinase complex, called the M-phase promoting factor, that induces entry into mitosis and is universal among eukaryotes. In HeLa cells, cdc2 is shown to be the most abundant phosphotyrosine-containing protein and its phosphotyrosine content is subject to cell-cycle regulation. One site ofcdc2 tyrosine phosphorylation in vivo W selectively phosphorylated by pp60^c-src in vitro.

Original language	English (US)
Pages (from-to)	738-744
Number of pages	7
Journal	Nature
Volume	336
Issue number	6201
DOIs	https://doi.org/10.1038/336738a0
State	Published - 1988
Externally published	Yes

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title = "Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate",

abstract = "cdc2 is a catalytic subunit of a protein kinase complex, called the M-phase promoting factor, that induces entry into mitosis and is universal among eukaryotes. In HeLa cells, cdc2 is shown to be the most abundant phosphotyrosine-containing protein and its phosphotyrosine content is subject to cell-cycle regulation. One site ofcdc2 tyrosine phosphorylation in vivo W selectively phosphorylated by pp60c-src in vitro.",

author = "Giulio Draetta and Helen Piwnica-Worms and Deborah Morrison and Brian Druker and Thomas Roberts and David Beach",

year = "1988",

doi = "10.1038/336738a0",

language = "English (US)",

volume = "336",

pages = "738--744",

journal = "Nature",

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number = "6201",

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T1 - Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate

AU - Draetta, Giulio

AU - Piwnica-Worms, Helen

AU - Morrison, Deborah

AU - Druker, Brian

AU - Roberts, Thomas

AU - Beach, David

PY - 1988

Y1 - 1988

N2 - cdc2 is a catalytic subunit of a protein kinase complex, called the M-phase promoting factor, that induces entry into mitosis and is universal among eukaryotes. In HeLa cells, cdc2 is shown to be the most abundant phosphotyrosine-containing protein and its phosphotyrosine content is subject to cell-cycle regulation. One site ofcdc2 tyrosine phosphorylation in vivo W selectively phosphorylated by pp60c-src in vitro.

AB - cdc2 is a catalytic subunit of a protein kinase complex, called the M-phase promoting factor, that induces entry into mitosis and is universal among eukaryotes. In HeLa cells, cdc2 is shown to be the most abundant phosphotyrosine-containing protein and its phosphotyrosine content is subject to cell-cycle regulation. One site ofcdc2 tyrosine phosphorylation in vivo W selectively phosphorylated by pp60c-src in vitro.

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JF - Nature

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ER -

Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate

Abstract

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