Hs-troponin i followed by CT angiography improves acute coronary syndrome risk stratification accuracy and work-up in acute chest pain patients results from ROMICAT II trial

Maros Ferencik, Ting Liu, Thomas Mayrhofer, Stefan B. Puchner, Michael T. Lu, Pal Maurovich-Horvat, J. Hector Pope, Quynh A. Truong, James E. Udelson, W. Frank Peacock, Charles S. White, Pamela K. Woodard, Jerome L. Fleg, John T. Nagurney, James L. Januzzi, Udo Hoffmann

    Research output: Contribution to journalArticle

    23 Citations (Scopus)

    Abstract

    Objectives This study compared diagnostic accuracy of conventional troponin/traditional coronary artery disease (CAD) assessment and highly sensitive troponin (hsTn) I/advanced CAD assessment for acute coronary syndrome (ACS) during the index hospitalization. Background hsTnI and advanced assessment of CAD using coronary computed tomography angiography (CTA) are promising candidates to improve the accuracy of emergency department evaluation of patients with suspected ACS. Methods We performed an observational cohort study in patients with suspected ACS enrolled in the ROMICAT II (Rule Out Myocardial Infarction/Ischemia using Computer Assisted Tomography) trial and randomized to coronary CTA who also had hsTnI measurement at the time of the emergency department presentation. We assessed coronary CTA for traditional (no CAD, nonobstructive CAD, ≥50% stenosis) and advanced features of CAD (≥50% stenosis, high-risk plaque features: positive remodeling, low

    Original languageEnglish (US)
    Pages (from-to)1272-1281
    Number of pages10
    JournalJACC: Cardiovascular Imaging
    Volume8
    Issue number11
    DOIs
    StatePublished - Nov 1 2015

    Fingerprint

    Troponin
    Acute Pain
    Acute Coronary Syndrome
    Chest Pain
    Coronary Artery Disease
    Hospital Emergency Service
    Pathologic Constriction
    Troponin I
    Observational Studies
    Myocardial Ischemia
    Hospitalization
    Cohort Studies
    Myocardial Infarction
    Tomography
    Computed Tomography Angiography

    Keywords

    • acute coronary syndrome
    • coronary computed tomography angiography
    • coronary plaque
    • emergency department
    • highly sensitive troponin
    • risk stratification

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine
    • Radiology Nuclear Medicine and imaging

    Cite this

    Hs-troponin i followed by CT angiography improves acute coronary syndrome risk stratification accuracy and work-up in acute chest pain patients results from ROMICAT II trial. / Ferencik, Maros; Liu, Ting; Mayrhofer, Thomas; Puchner, Stefan B.; Lu, Michael T.; Maurovich-Horvat, Pal; Pope, J. Hector; Truong, Quynh A.; Udelson, James E.; Peacock, W. Frank; White, Charles S.; Woodard, Pamela K.; Fleg, Jerome L.; Nagurney, John T.; Januzzi, James L.; Hoffmann, Udo.

    In: JACC: Cardiovascular Imaging, Vol. 8, No. 11, 01.11.2015, p. 1272-1281.

    Research output: Contribution to journalArticle

    Ferencik, M, Liu, T, Mayrhofer, T, Puchner, SB, Lu, MT, Maurovich-Horvat, P, Pope, JH, Truong, QA, Udelson, JE, Peacock, WF, White, CS, Woodard, PK, Fleg, JL, Nagurney, JT, Januzzi, JL & Hoffmann, U 2015, 'Hs-troponin i followed by CT angiography improves acute coronary syndrome risk stratification accuracy and work-up in acute chest pain patients results from ROMICAT II trial', JACC: Cardiovascular Imaging, vol. 8, no. 11, pp. 1272-1281. https://doi.org/10.1016/j.jcmg.2015.06.016
    Ferencik, Maros ; Liu, Ting ; Mayrhofer, Thomas ; Puchner, Stefan B. ; Lu, Michael T. ; Maurovich-Horvat, Pal ; Pope, J. Hector ; Truong, Quynh A. ; Udelson, James E. ; Peacock, W. Frank ; White, Charles S. ; Woodard, Pamela K. ; Fleg, Jerome L. ; Nagurney, John T. ; Januzzi, James L. ; Hoffmann, Udo. / Hs-troponin i followed by CT angiography improves acute coronary syndrome risk stratification accuracy and work-up in acute chest pain patients results from ROMICAT II trial. In: JACC: Cardiovascular Imaging. 2015 ; Vol. 8, No. 11. pp. 1272-1281.
    @article{d2ec573290c84d56aed6002ba95b3a58,
    title = "Hs-troponin i followed by CT angiography improves acute coronary syndrome risk stratification accuracy and work-up in acute chest pain patients results from ROMICAT II trial",
    abstract = "Objectives This study compared diagnostic accuracy of conventional troponin/traditional coronary artery disease (CAD) assessment and highly sensitive troponin (hsTn) I/advanced CAD assessment for acute coronary syndrome (ACS) during the index hospitalization. Background hsTnI and advanced assessment of CAD using coronary computed tomography angiography (CTA) are promising candidates to improve the accuracy of emergency department evaluation of patients with suspected ACS. Methods We performed an observational cohort study in patients with suspected ACS enrolled in the ROMICAT II (Rule Out Myocardial Infarction/Ischemia using Computer Assisted Tomography) trial and randomized to coronary CTA who also had hsTnI measurement at the time of the emergency department presentation. We assessed coronary CTA for traditional (no CAD, nonobstructive CAD, ≥50{\%} stenosis) and advanced features of CAD (≥50{\%} stenosis, high-risk plaque features: positive remodeling, low",
    keywords = "acute coronary syndrome, coronary computed tomography angiography, coronary plaque, emergency department, highly sensitive troponin, risk stratification",
    author = "Maros Ferencik and Ting Liu and Thomas Mayrhofer and Puchner, {Stefan B.} and Lu, {Michael T.} and Pal Maurovich-Horvat and Pope, {J. Hector} and Truong, {Quynh A.} and Udelson, {James E.} and Peacock, {W. Frank} and White, {Charles S.} and Woodard, {Pamela K.} and Fleg, {Jerome L.} and Nagurney, {John T.} and Januzzi, {James L.} and Udo Hoffmann",
    year = "2015",
    month = "11",
    day = "1",
    doi = "10.1016/j.jcmg.2015.06.016",
    language = "English (US)",
    volume = "8",
    pages = "1272--1281",
    journal = "JACC: Cardiovascular Imaging",
    issn = "1936-878X",
    publisher = "Elsevier Inc.",
    number = "11",

    }

    TY - JOUR

    T1 - Hs-troponin i followed by CT angiography improves acute coronary syndrome risk stratification accuracy and work-up in acute chest pain patients results from ROMICAT II trial

    AU - Ferencik, Maros

    AU - Liu, Ting

    AU - Mayrhofer, Thomas

    AU - Puchner, Stefan B.

    AU - Lu, Michael T.

    AU - Maurovich-Horvat, Pal

    AU - Pope, J. Hector

    AU - Truong, Quynh A.

    AU - Udelson, James E.

    AU - Peacock, W. Frank

    AU - White, Charles S.

    AU - Woodard, Pamela K.

    AU - Fleg, Jerome L.

    AU - Nagurney, John T.

    AU - Januzzi, James L.

    AU - Hoffmann, Udo

    PY - 2015/11/1

    Y1 - 2015/11/1

    N2 - Objectives This study compared diagnostic accuracy of conventional troponin/traditional coronary artery disease (CAD) assessment and highly sensitive troponin (hsTn) I/advanced CAD assessment for acute coronary syndrome (ACS) during the index hospitalization. Background hsTnI and advanced assessment of CAD using coronary computed tomography angiography (CTA) are promising candidates to improve the accuracy of emergency department evaluation of patients with suspected ACS. Methods We performed an observational cohort study in patients with suspected ACS enrolled in the ROMICAT II (Rule Out Myocardial Infarction/Ischemia using Computer Assisted Tomography) trial and randomized to coronary CTA who also had hsTnI measurement at the time of the emergency department presentation. We assessed coronary CTA for traditional (no CAD, nonobstructive CAD, ≥50% stenosis) and advanced features of CAD (≥50% stenosis, high-risk plaque features: positive remodeling, low

    AB - Objectives This study compared diagnostic accuracy of conventional troponin/traditional coronary artery disease (CAD) assessment and highly sensitive troponin (hsTn) I/advanced CAD assessment for acute coronary syndrome (ACS) during the index hospitalization. Background hsTnI and advanced assessment of CAD using coronary computed tomography angiography (CTA) are promising candidates to improve the accuracy of emergency department evaluation of patients with suspected ACS. Methods We performed an observational cohort study in patients with suspected ACS enrolled in the ROMICAT II (Rule Out Myocardial Infarction/Ischemia using Computer Assisted Tomography) trial and randomized to coronary CTA who also had hsTnI measurement at the time of the emergency department presentation. We assessed coronary CTA for traditional (no CAD, nonobstructive CAD, ≥50% stenosis) and advanced features of CAD (≥50% stenosis, high-risk plaque features: positive remodeling, low

    KW - acute coronary syndrome

    KW - coronary computed tomography angiography

    KW - coronary plaque

    KW - emergency department

    KW - highly sensitive troponin

    KW - risk stratification

    UR - http://www.scopus.com/inward/record.url?scp=84946738079&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84946738079&partnerID=8YFLogxK

    U2 - 10.1016/j.jcmg.2015.06.016

    DO - 10.1016/j.jcmg.2015.06.016

    M3 - Article

    C2 - 26476506

    AN - SCOPUS:84946738079

    VL - 8

    SP - 1272

    EP - 1281

    JO - JACC: Cardiovascular Imaging

    JF - JACC: Cardiovascular Imaging

    SN - 1936-878X

    IS - 11

    ER -