How Tumor Cells Make Use of CD44

Peter Herrlich, Jonathan Sleeman, David Wainwright, Harald König, Larry Sherman, Frank Hilberg, Helmut Ponta

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

A variant of CD44 containing exon v3 sequences is expressed in the apical ectodermal ridge of the limb bud during embryogenesis. This variant is modified by heparan sulfate moieties and acts as low affinity receptor for FGFs. These FGFs are presented by CD44 to mesenchymal cells which induces their proliferation and limb outgrowth. We suggest that a similar growthfactor presentation mechanism accounts for the function of CD44 variants on metastasizing tumor cells.

Original languageEnglish (US)
Pages (from-to)141-147
Number of pages7
JournalCell Communication and Adhesion
Volume6
Issue number2-3
DOIs
StatePublished - 1998
Externally publishedYes

Keywords

  • CD44 variants
  • Growth factor presentation
  • Limb formation
  • Tumor metastasis

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology

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