How Tumor Cells Make Use of CD44

Peter Herrlich, Jonathan Sleeman, David Wainwright, Harald König, Larry Sherman, Frank Hilberg, Helmut Ponta

    Research output: Contribution to journalArticle

    37 Scopus citations

    Abstract

    A variant of CD44 containing exon v3 sequences is expressed in the apical ectodermal ridge of the limb bud during embryogenesis. This variant is modified by heparan sulfate moieties and acts as low affinity receptor for FGFs. These FGFs are presented by CD44 to mesenchymal cells which induces their proliferation and limb outgrowth. We suggest that a similar growthfactor presentation mechanism accounts for the function of CD44 variants on metastasizing tumor cells.

    Original languageEnglish (US)
    Pages (from-to)141-147
    Number of pages7
    JournalCell Communication and Adhesion
    Volume6
    Issue number2-3
    DOIs
    StatePublished - Jan 1 1998

    Keywords

    • CD44 variants
    • Growth factor presentation
    • Limb formation
    • Tumor metastasis

    ASJC Scopus subject areas

    • Clinical Biochemistry
    • Cell Biology

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  • Cite this

    Herrlich, P., Sleeman, J., Wainwright, D., König, H., Sherman, L., Hilberg, F., & Ponta, H. (1998). How Tumor Cells Make Use of CD44. Cell Communication and Adhesion, 6(2-3), 141-147. https://doi.org/10.3109/15419069809004470