How tumor cells make use of CD44

P. Herrlich, J. Sleeman, D. Wainwright, H. Konig, Lawrence (Larry) Sherman, F. Hilberg, H. Ponta

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

A variant of CD44 containing exon v3 sequences is expressed in the apical ectodermal ridge of the limb bud during embryogenesis. This variant is modified by heparan sulfate moieties and acts as low affinity receptor for FGFs. These FGFs are presented by CD44 to mesenchymal cells which induces their proliferation and limb outgrowth. We suggest that a similar growth factor presentation mechanism accounts for the function of CD44 variants on metastasizing tumor cells.

Original languageEnglish (US)
Pages (from-to)141-147
Number of pages7
JournalCell Adhesion and Communication
Volume6
Issue number2-3
StatePublished - 1998
Externally publishedYes

Fingerprint

Fibroblast Growth Factor Receptors
Heparitin Sulfate
Tumors
Exons
Intercellular Signaling Peptides and Proteins
Cells
Limb Buds
Embryonic Development
Neoplasms
Extremities

Keywords

  • CD44 variants
  • Growth factor presentation
  • Limb formation
  • Tumor metastasis

ASJC Scopus subject areas

  • Cell Biology
  • Clinical Biochemistry

Cite this

Herrlich, P., Sleeman, J., Wainwright, D., Konig, H., Sherman, L. L., Hilberg, F., & Ponta, H. (1998). How tumor cells make use of CD44. Cell Adhesion and Communication, 6(2-3), 141-147.

How tumor cells make use of CD44. / Herrlich, P.; Sleeman, J.; Wainwright, D.; Konig, H.; Sherman, Lawrence (Larry); Hilberg, F.; Ponta, H.

In: Cell Adhesion and Communication, Vol. 6, No. 2-3, 1998, p. 141-147.

Research output: Contribution to journalArticle

Herrlich, P, Sleeman, J, Wainwright, D, Konig, H, Sherman, LL, Hilberg, F & Ponta, H 1998, 'How tumor cells make use of CD44', Cell Adhesion and Communication, vol. 6, no. 2-3, pp. 141-147.
Herrlich P, Sleeman J, Wainwright D, Konig H, Sherman LL, Hilberg F et al. How tumor cells make use of CD44. Cell Adhesion and Communication. 1998;6(2-3):141-147.
Herrlich, P. ; Sleeman, J. ; Wainwright, D. ; Konig, H. ; Sherman, Lawrence (Larry) ; Hilberg, F. ; Ponta, H. / How tumor cells make use of CD44. In: Cell Adhesion and Communication. 1998 ; Vol. 6, No. 2-3. pp. 141-147.
@article{797025adb0994a73a3b529cd36cb8442,
title = "How tumor cells make use of CD44",
abstract = "A variant of CD44 containing exon v3 sequences is expressed in the apical ectodermal ridge of the limb bud during embryogenesis. This variant is modified by heparan sulfate moieties and acts as low affinity receptor for FGFs. These FGFs are presented by CD44 to mesenchymal cells which induces their proliferation and limb outgrowth. We suggest that a similar growth factor presentation mechanism accounts for the function of CD44 variants on metastasizing tumor cells.",
keywords = "CD44 variants, Growth factor presentation, Limb formation, Tumor metastasis",
author = "P. Herrlich and J. Sleeman and D. Wainwright and H. Konig and Sherman, {Lawrence (Larry)} and F. Hilberg and H. Ponta",
year = "1998",
language = "English (US)",
volume = "6",
pages = "141--147",
journal = "Cell Communication and Adhesion",
issn = "1541-9061",
publisher = "Informa Healthcare",
number = "2-3",

}

TY - JOUR

T1 - How tumor cells make use of CD44

AU - Herrlich, P.

AU - Sleeman, J.

AU - Wainwright, D.

AU - Konig, H.

AU - Sherman, Lawrence (Larry)

AU - Hilberg, F.

AU - Ponta, H.

PY - 1998

Y1 - 1998

N2 - A variant of CD44 containing exon v3 sequences is expressed in the apical ectodermal ridge of the limb bud during embryogenesis. This variant is modified by heparan sulfate moieties and acts as low affinity receptor for FGFs. These FGFs are presented by CD44 to mesenchymal cells which induces their proliferation and limb outgrowth. We suggest that a similar growth factor presentation mechanism accounts for the function of CD44 variants on metastasizing tumor cells.

AB - A variant of CD44 containing exon v3 sequences is expressed in the apical ectodermal ridge of the limb bud during embryogenesis. This variant is modified by heparan sulfate moieties and acts as low affinity receptor for FGFs. These FGFs are presented by CD44 to mesenchymal cells which induces their proliferation and limb outgrowth. We suggest that a similar growth factor presentation mechanism accounts for the function of CD44 variants on metastasizing tumor cells.

KW - CD44 variants

KW - Growth factor presentation

KW - Limb formation

KW - Tumor metastasis

UR - http://www.scopus.com/inward/record.url?scp=0031796198&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031796198&partnerID=8YFLogxK

M3 - Article

C2 - 9823465

AN - SCOPUS:0031796198

VL - 6

SP - 141

EP - 147

JO - Cell Communication and Adhesion

JF - Cell Communication and Adhesion

SN - 1541-9061

IS - 2-3

ER -