How to build a healthy heart from scratch

Kent Thornburg, John R G Challis

    Research output: Chapter in Book/Report/Conference proceedingChapter

    4 Citations (Scopus)

    Abstract

    By any of several measures, the health of the American population has been worsening over the last two decades. Obesity, type 2 diabetes and heart failure have risen dramatically. All the while, the average birthweight at all gestational ages has declined. The relationship between robust growth in the womb and lifelong health is now well established. Likewise, babies born at the low end of the birthweight scale are known to have highly elevated risks for ischemic heart disease, hypertension, stroke and metabolic disease. The biological mechanisms by which developmental plasticity becomes a risk for cardiovascular disease are only now being understood. Translating from animal and human studies, low birthweight babies are likely to have endothelial dysfunction, fewer nephrons, fewer pancreatic beta cells, less vascular elastin, fewer cardiomyocytes, increased sympathetic tone and liver-derived dyslipidemias. Only in the past few years, however, has it become known that maternal and placenta phenotypes are associated with adult onset cardiovascular disease. Helsinki Birth Cohort studies have been especially important in the discovery of these relationships. Sudden cardiac death is associated with a thin placenta and heart failure is associated with a small placenta in short mothers. Coronary heart disease is associated with three combinations of maternal-placental phenotypes. Because the diet is important in providing nutrients for the development of the female body before pregnancy and for providing nutrients during pregnancy, there is increasing evidence that the western diet is an underlying cause for the increase in metabolic disease in the American population. A large segment of the American population suffers from high calorie malnutrition. Scientists in this field now have a responsibility to educate the public on the topic of nutrition and health. This chapter honors Lawrence Longo for decades of work in bringing health to pregnant women and their babies.

    Original languageEnglish (US)
    Title of host publicationAdvances in Experimental Medicine and Biology
    PublisherSpringer New York LLC
    Pages205-216
    Number of pages12
    Volume814
    ISBN (Print)9781493910304
    DOIs
    StatePublished - 2014

    Publication series

    NameAdvances in Experimental Medicine and Biology
    Volume814
    ISSN (Print)00652598
    ISSN (Electronic)22148019

    Fingerprint

    Placenta
    Metabolic Diseases
    Mothers
    Health
    Nutrition
    Cardiovascular Diseases
    Heart Failure
    Population
    Phenotype
    Food
    Pregnancy
    Nutrients
    Elastin
    Sudden Cardiac Death
    Nephrons
    Insulin-Secreting Cells
    Dyslipidemias
    Cardiac Myocytes
    Malnutrition
    Type 2 Diabetes Mellitus

    Keywords

    • Cardiac myocytes
    • Cardiovascular disease
    • Fetal programming
    • High calorie malnutrition
    • Placental phenotype

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)
    • Medicine(all)

    Cite this

    Thornburg, K., & Challis, J. R. G. (2014). How to build a healthy heart from scratch. In Advances in Experimental Medicine and Biology (Vol. 814, pp. 205-216). (Advances in Experimental Medicine and Biology; Vol. 814). Springer New York LLC. https://doi.org/10.1007/978-1-4939-1031-1_18

    How to build a healthy heart from scratch. / Thornburg, Kent; Challis, John R G.

    Advances in Experimental Medicine and Biology. Vol. 814 Springer New York LLC, 2014. p. 205-216 (Advances in Experimental Medicine and Biology; Vol. 814).

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Thornburg, K & Challis, JRG 2014, How to build a healthy heart from scratch. in Advances in Experimental Medicine and Biology. vol. 814, Advances in Experimental Medicine and Biology, vol. 814, Springer New York LLC, pp. 205-216. https://doi.org/10.1007/978-1-4939-1031-1_18
    Thornburg K, Challis JRG. How to build a healthy heart from scratch. In Advances in Experimental Medicine and Biology. Vol. 814. Springer New York LLC. 2014. p. 205-216. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-4939-1031-1_18
    Thornburg, Kent ; Challis, John R G. / How to build a healthy heart from scratch. Advances in Experimental Medicine and Biology. Vol. 814 Springer New York LLC, 2014. pp. 205-216 (Advances in Experimental Medicine and Biology).
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