TY - JOUR
T1 - How LeuT shapes our understanding of the mechanisms of sodium-coupled neurotransmitter transporters
AU - Penmatsa, Aravind
AU - Gouaux, Eric
PY - 2014/3/1
Y1 - 2014/3/1
N2 - Neurotransmitter transporters are ion-coupled symporters that drive the uptake of neurotransmitters from neural synapses. In the past decade, the structure of a bacterial amino acid transporter, leucine transporter (LeuT), has given valuable insights into the understanding of architecture and mechanism of mammalian neurotransmitter transporters. Different conformations of LeuT, including a substrate-free state, inward-open state, and competitive and non-competitive inhibitor-bound states, have revealed a mechanistic framework for the transport and transport inhibition of neurotransmitters. The current review integrates our understanding of the mechanistic and pharmacological properties of eukaryotic neurotransmitter transporters obtained through structural snapshots of LeuT.
AB - Neurotransmitter transporters are ion-coupled symporters that drive the uptake of neurotransmitters from neural synapses. In the past decade, the structure of a bacterial amino acid transporter, leucine transporter (LeuT), has given valuable insights into the understanding of architecture and mechanism of mammalian neurotransmitter transporters. Different conformations of LeuT, including a substrate-free state, inward-open state, and competitive and non-competitive inhibitor-bound states, have revealed a mechanistic framework for the transport and transport inhibition of neurotransmitters. The current review integrates our understanding of the mechanistic and pharmacological properties of eukaryotic neurotransmitter transporters obtained through structural snapshots of LeuT.
UR - http://www.scopus.com/inward/record.url?scp=84894830041&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84894830041&partnerID=8YFLogxK
U2 - 10.1113/jphysiol.2013.259051
DO - 10.1113/jphysiol.2013.259051
M3 - Article
C2 - 23878376
AN - SCOPUS:84894830041
SN - 0022-3751
VL - 592
SP - 863
EP - 869
JO - Journal of Physiology
JF - Journal of Physiology
IS - 5
ER -