How do opiates inhibit neurotransmitter release?

R. Alan North, John Williams

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Opiates and opioid peptides inhibit the discharge of nerve cells. This action has been considered to result from 'postsynaptic' inhibition of cell firing, or from a 'presynaptic' reduction in the release of excitatory transmitters. In cells of the myenteric plexus and locus coeruleus, opiates directly inhibit cell firing by opening membrane potassium channels and hyperpolarizing the membrane. A hyperpolarization also occurs on nerve cell processes; this can lead to a reduction in transmitter release by blocking action potential propagation and by reducing the entry of calcium during the action potential. Thus both forms of inhibition may result from a single ionic mechanism -an increase in membrane potassium conductance.

Original languageEnglish (US)
Pages (from-to)337-339
Number of pages3
JournalTrends in Neurosciences
Volume6
Issue numberC
DOIs
StatePublished - 1983
Externally publishedYes

Fingerprint

Opiate Alkaloids
Neurotransmitter Agents
Opioid Peptides
Action Potentials
Neurons
Myenteric Plexus
Locus Coeruleus
Membranes
Potassium Channels
Ion Channels
Potassium
Calcium

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

How do opiates inhibit neurotransmitter release? / North, R. Alan; Williams, John.

In: Trends in Neurosciences, Vol. 6, No. C, 1983, p. 337-339.

Research output: Contribution to journalArticle

North, R. Alan ; Williams, John. / How do opiates inhibit neurotransmitter release?. In: Trends in Neurosciences. 1983 ; Vol. 6, No. C. pp. 337-339.
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