Host-tumor interactions influencing cancer progression

Barbara Fingleton, Lisa M. Coussens

Research output: Contribution to journalReview article

Abstract

Our appreciation of the complexity of tumor biology has led us from considering tumors as autonomous masses of mutant cells to an awareness of the insidious nature of tumors as entities that can hijack and exploit various normal physiologic processes of the host. In this article, we will explore the recent developments in our understanding of how the immune system, extracellular matrix metabolism, interactions with fibroblasts and angiogenesis affect tumor development.

Original languageEnglish (US)
Pages (from-to)199-204
Number of pages6
JournalDrug Discovery Today: Disease Mechanisms
Volume2
Issue number2
DOIs
StatePublished - Dec 1 2005

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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