Host-tumor interactions influencing cancer progression

Barbara Fingleton, Lisa Coussens

Research output: Contribution to journalArticle

Abstract

Our appreciation of the complexity of tumor biology has led us from considering tumors as autonomous masses of mutant cells to an awareness of the insidious nature of tumors as entities that can hijack and exploit various normal physiologic processes of the host. In this article, we will explore the recent developments in our understanding of how the immune system, extracellular matrix metabolism, interactions with fibroblasts and angiogenesis affect tumor development.

Original languageEnglish (US)
Pages (from-to)199-204
Number of pages6
JournalDrug Discovery Today: Disease Mechanisms
Volume2
Issue number2
DOIs
StatePublished - 2005
Externally publishedYes

Fingerprint

Neoplasms
Extracellular Matrix
Immune System
Fibroblasts

ASJC Scopus subject areas

  • Drug Discovery
  • Molecular Medicine

Cite this

Host-tumor interactions influencing cancer progression. / Fingleton, Barbara; Coussens, Lisa.

In: Drug Discovery Today: Disease Mechanisms, Vol. 2, No. 2, 2005, p. 199-204.

Research output: Contribution to journalArticle

@article{ee3704f4826140d6ab6e38fb88a04ee6,
title = "Host-tumor interactions influencing cancer progression",
abstract = "Our appreciation of the complexity of tumor biology has led us from considering tumors as autonomous masses of mutant cells to an awareness of the insidious nature of tumors as entities that can hijack and exploit various normal physiologic processes of the host. In this article, we will explore the recent developments in our understanding of how the immune system, extracellular matrix metabolism, interactions with fibroblasts and angiogenesis affect tumor development.",
author = "Barbara Fingleton and Lisa Coussens",
year = "2005",
doi = "10.1016/j.ddmec.2005.05.002",
language = "English (US)",
volume = "2",
pages = "199--204",
journal = "Drug Discovery Today: Disease Mechanisms",
issn = "1740-6765",
publisher = "Elsevier Limited",
number = "2",

}

TY - JOUR

T1 - Host-tumor interactions influencing cancer progression

AU - Fingleton, Barbara

AU - Coussens, Lisa

PY - 2005

Y1 - 2005

N2 - Our appreciation of the complexity of tumor biology has led us from considering tumors as autonomous masses of mutant cells to an awareness of the insidious nature of tumors as entities that can hijack and exploit various normal physiologic processes of the host. In this article, we will explore the recent developments in our understanding of how the immune system, extracellular matrix metabolism, interactions with fibroblasts and angiogenesis affect tumor development.

AB - Our appreciation of the complexity of tumor biology has led us from considering tumors as autonomous masses of mutant cells to an awareness of the insidious nature of tumors as entities that can hijack and exploit various normal physiologic processes of the host. In this article, we will explore the recent developments in our understanding of how the immune system, extracellular matrix metabolism, interactions with fibroblasts and angiogenesis affect tumor development.

UR - http://www.scopus.com/inward/record.url?scp=33645062662&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645062662&partnerID=8YFLogxK

U2 - 10.1016/j.ddmec.2005.05.002

DO - 10.1016/j.ddmec.2005.05.002

M3 - Article

VL - 2

SP - 199

EP - 204

JO - Drug Discovery Today: Disease Mechanisms

JF - Drug Discovery Today: Disease Mechanisms

SN - 1740-6765

IS - 2

ER -