Host-tumor interactions influencing cancer progression

Barbara Fingleton; Lisa M. Coussens

doi:10.1016/j.ddmec.2005.05.002

Host-tumor interactions influencing cancer progression

Research output: Contribution to journal › Review article › peer-review

Abstract

Our appreciation of the complexity of tumor biology has led us from considering tumors as autonomous masses of mutant cells to an awareness of the insidious nature of tumors as entities that can hijack and exploit various normal physiologic processes of the host. In this article, we will explore the recent developments in our understanding of how the immune system, extracellular matrix metabolism, interactions with fibroblasts and angiogenesis affect tumor development.

Original language	English (US)
Pages (from-to)	199-204
Number of pages	6
Journal	Drug Discovery Today: Disease Mechanisms
Volume	2
Issue number	2
DOIs	https://doi.org/10.1016/j.ddmec.2005.05.002
State	Published - Dec 1 2005
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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10.1016/j.ddmec.2005.05.002

Cite this

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title = "Host-tumor interactions influencing cancer progression",

abstract = "Our appreciation of the complexity of tumor biology has led us from considering tumors as autonomous masses of mutant cells to an awareness of the insidious nature of tumors as entities that can hijack and exploit various normal physiologic processes of the host. In this article, we will explore the recent developments in our understanding of how the immune system, extracellular matrix metabolism, interactions with fibroblasts and angiogenesis affect tumor development.",

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AU - Coussens, Lisa M.

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AB - Our appreciation of the complexity of tumor biology has led us from considering tumors as autonomous masses of mutant cells to an awareness of the insidious nature of tumors as entities that can hijack and exploit various normal physiologic processes of the host. In this article, we will explore the recent developments in our understanding of how the immune system, extracellular matrix metabolism, interactions with fibroblasts and angiogenesis affect tumor development.

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DO - 10.1016/j.ddmec.2005.05.002

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AN - SCOPUS:33645062662

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Host-tumor interactions influencing cancer progression

Abstract

ASJC Scopus subject areas

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