Hormone Supplementation during aging: How much and when?

K. G. Sorwell, J. Garten, L. Renner, A. Weiss, V. T. Garyfallou, Steven Kohama, Martha Neuringer, Henryk Urbanski

    Research output: Contribution to journalArticle

    6 Citations (Scopus)

    Abstract

    Circulating levels of dehydroepiandrosterone, a major adrenal steroid, show a marked age-related decrease in both humans and nonhuman primates. Because this decrease has been implicated in age-related cognitive decline, we administered supplementary dehydroepiandrosterone to perimenopausal rhesus macaques (Macaca mulatta) to test for cognitive benefits. Although recognition memory improved, there was no benefit to spatial working memory. To address the limitations of this study we developed a hormone supplementation regimen in aged male macaques that more accurately replicates the 24-hr androgen profiles of young animals. We hypothesize that this more comprehensive physiological hormone replacement paradigm will enhance cognitive function in the elderly.

    Original languageEnglish (US)
    Pages (from-to)128-131
    Number of pages4
    JournalRejuvenation Research
    Volume15
    Issue number2
    DOIs
    StatePublished - Apr 1 2012

    Fingerprint

    Dehydroepiandrosterone
    Macaca mulatta
    Hormones
    Macaca
    Short-Term Memory
    Cognition
    Primates
    Androgens
    Steroids
    Spatial Memory
    Recognition (Psychology)
    Cognitive Dysfunction

    ASJC Scopus subject areas

    • Aging
    • Geriatrics and Gerontology

    Cite this

    Sorwell, K. G., Garten, J., Renner, L., Weiss, A., Garyfallou, V. T., Kohama, S., ... Urbanski, H. (2012). Hormone Supplementation during aging: How much and when? Rejuvenation Research, 15(2), 128-131. https://doi.org/10.1089/rej.2011.1251

    Hormone Supplementation during aging : How much and when? / Sorwell, K. G.; Garten, J.; Renner, L.; Weiss, A.; Garyfallou, V. T.; Kohama, Steven; Neuringer, Martha; Urbanski, Henryk.

    In: Rejuvenation Research, Vol. 15, No. 2, 01.04.2012, p. 128-131.

    Research output: Contribution to journalArticle

    Sorwell, KG, Garten, J, Renner, L, Weiss, A, Garyfallou, VT, Kohama, S, Neuringer, M & Urbanski, H 2012, 'Hormone Supplementation during aging: How much and when?', Rejuvenation Research, vol. 15, no. 2, pp. 128-131. https://doi.org/10.1089/rej.2011.1251
    Sorwell KG, Garten J, Renner L, Weiss A, Garyfallou VT, Kohama S et al. Hormone Supplementation during aging: How much and when? Rejuvenation Research. 2012 Apr 1;15(2):128-131. https://doi.org/10.1089/rej.2011.1251
    Sorwell, K. G. ; Garten, J. ; Renner, L. ; Weiss, A. ; Garyfallou, V. T. ; Kohama, Steven ; Neuringer, Martha ; Urbanski, Henryk. / Hormone Supplementation during aging : How much and when?. In: Rejuvenation Research. 2012 ; Vol. 15, No. 2. pp. 128-131.
    @article{49493c93849c47dabf6bbc48f1203f8e,
    title = "Hormone Supplementation during aging: How much and when?",
    abstract = "Circulating levels of dehydroepiandrosterone, a major adrenal steroid, show a marked age-related decrease in both humans and nonhuman primates. Because this decrease has been implicated in age-related cognitive decline, we administered supplementary dehydroepiandrosterone to perimenopausal rhesus macaques (Macaca mulatta) to test for cognitive benefits. Although recognition memory improved, there was no benefit to spatial working memory. To address the limitations of this study we developed a hormone supplementation regimen in aged male macaques that more accurately replicates the 24-hr androgen profiles of young animals. We hypothesize that this more comprehensive physiological hormone replacement paradigm will enhance cognitive function in the elderly.",
    author = "Sorwell, {K. G.} and J. Garten and L. Renner and A. Weiss and Garyfallou, {V. T.} and Steven Kohama and Martha Neuringer and Henryk Urbanski",
    year = "2012",
    month = "4",
    day = "1",
    doi = "10.1089/rej.2011.1251",
    language = "English (US)",
    volume = "15",
    pages = "128--131",
    journal = "Rejuvenation Research",
    issn = "1549-1684",
    publisher = "Mary Ann Liebert Inc.",
    number = "2",

    }

    TY - JOUR

    T1 - Hormone Supplementation during aging

    T2 - How much and when?

    AU - Sorwell, K. G.

    AU - Garten, J.

    AU - Renner, L.

    AU - Weiss, A.

    AU - Garyfallou, V. T.

    AU - Kohama, Steven

    AU - Neuringer, Martha

    AU - Urbanski, Henryk

    PY - 2012/4/1

    Y1 - 2012/4/1

    N2 - Circulating levels of dehydroepiandrosterone, a major adrenal steroid, show a marked age-related decrease in both humans and nonhuman primates. Because this decrease has been implicated in age-related cognitive decline, we administered supplementary dehydroepiandrosterone to perimenopausal rhesus macaques (Macaca mulatta) to test for cognitive benefits. Although recognition memory improved, there was no benefit to spatial working memory. To address the limitations of this study we developed a hormone supplementation regimen in aged male macaques that more accurately replicates the 24-hr androgen profiles of young animals. We hypothesize that this more comprehensive physiological hormone replacement paradigm will enhance cognitive function in the elderly.

    AB - Circulating levels of dehydroepiandrosterone, a major adrenal steroid, show a marked age-related decrease in both humans and nonhuman primates. Because this decrease has been implicated in age-related cognitive decline, we administered supplementary dehydroepiandrosterone to perimenopausal rhesus macaques (Macaca mulatta) to test for cognitive benefits. Although recognition memory improved, there was no benefit to spatial working memory. To address the limitations of this study we developed a hormone supplementation regimen in aged male macaques that more accurately replicates the 24-hr androgen profiles of young animals. We hypothesize that this more comprehensive physiological hormone replacement paradigm will enhance cognitive function in the elderly.

    UR - http://www.scopus.com/inward/record.url?scp=84860309959&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84860309959&partnerID=8YFLogxK

    U2 - 10.1089/rej.2011.1251

    DO - 10.1089/rej.2011.1251

    M3 - Article

    C2 - 22533414

    AN - SCOPUS:84860309959

    VL - 15

    SP - 128

    EP - 131

    JO - Rejuvenation Research

    JF - Rejuvenation Research

    SN - 1549-1684

    IS - 2

    ER -