Hormonal responses to the six-minute walk test in women (W) and men (M) with coronary artery disease (CAD)

K. J. Radke, K. B. King, M. L. Blair, P. G. Fitzpatrick, Deborah Eldredge

Research output: Contribution to journalArticle

Abstract

We determined efficacy of the 6-min walk test (exercise) as a stimulus for release of hormones associated with sympathetic activation and fluid/electrolyte regulation in W and M with CAD. Nine W and 9 M with arteriographically-documented CAD and normal LV ejection fractions were matched for age (66 ± 8 yrs) and hypertension; none of the subjects had diabetes mellitus. Maintenance drugs included ACE inhibitors (2W;3M), B-blockers (7W;1M), Ca-channel blockers (1W;2M), diuretics (2W;0M), and nitroglycerin (3W;3M). After venipuncture and 30 min of supine rest, basal blood samples were drawn. Subjects then walked for 6 min to cover as much distance as possible. Post-exercise blood samples were drawn. Basal levels of vasopressin (VP) were significantly higher in M (1.02 ± 0.17 pg/ml) than in W (0.61 ± 0.01 pg/ml). There were no gender differences for basal levels of atrial natriuretic peptide (ANP), plasma renin activity (PRA), norepinephrine (NE), epinephrine (E), cortisol or aldosterone. Exercise for W and M combined significantly increased VP (0.81 ± 0.09 basal to 1.05 ± 0.12 pg/ml post-exercise), ANP (84 ± 20 to 134 ± 25 pg/ml), and NE (240 ± 23 to 448 ± 54 pg/ml) but not PRA (4.40 ± 1.84 to 6.14 ± 2.79 ng/ml/hr) or E (23 ± 1 to 26 ± 2 pg/ml). There were no gender differences for the magnitude of exercise-induced increases for VP, ANP, PRA, NE or E. Conclusions: a gender difference occurred only for basal VP levels; the 6-min walk test is an exercise stressor of sufficient intensity and duration to significantly increase VP, ANP and NE in both W and M with CAD.

Original languageEnglish (US)
JournalFASEB Journal
Volume12
Issue number5
StatePublished - Mar 20 1998
Externally publishedYes

Fingerprint

vasopressin
atrial natriuretic peptide
Vasopressins
Atrial Natriuretic Factor
Coronary Artery Disease
norepinephrine
exercise
renin
Norepinephrine
Renin
gender differences
Exercise
Plasmas
testing
Blood
aldosterone
exercise test
diuretics
Phlebotomy
blood

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Radke, K. J., King, K. B., Blair, M. L., Fitzpatrick, P. G., & Eldredge, D. (1998). Hormonal responses to the six-minute walk test in women (W) and men (M) with coronary artery disease (CAD). FASEB Journal, 12(5).

Hormonal responses to the six-minute walk test in women (W) and men (M) with coronary artery disease (CAD). / Radke, K. J.; King, K. B.; Blair, M. L.; Fitzpatrick, P. G.; Eldredge, Deborah.

In: FASEB Journal, Vol. 12, No. 5, 20.03.1998.

Research output: Contribution to journalArticle

Radke, KJ, King, KB, Blair, ML, Fitzpatrick, PG & Eldredge, D 1998, 'Hormonal responses to the six-minute walk test in women (W) and men (M) with coronary artery disease (CAD)', FASEB Journal, vol. 12, no. 5.
Radke, K. J. ; King, K. B. ; Blair, M. L. ; Fitzpatrick, P. G. ; Eldredge, Deborah. / Hormonal responses to the six-minute walk test in women (W) and men (M) with coronary artery disease (CAD). In: FASEB Journal. 1998 ; Vol. 12, No. 5.
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