TY - JOUR
T1 - Hormonal responses to the 6-minute walk test in women and men with coronary heart disease
T2 - A pilot study
AU - Radke, Karen J.
AU - King, Kathleen B.
AU - Blair, Martha L.
AU - Fitzpatrick, Patricia G.
AU - Eldredge, Deborah H.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2005
Y1 - 2005
N2 - BACKGROUND: Women with coronary heart disease (CHD) are more likely than men to develop congestive heart failure (CHF). Dysregulation of sympathetic and volume-regulatory hormones may contribute to the onset of symptomatic CHF. We hypothesized that this hormonal dysregulation develops at an earlier stage of CHD in women than in men. OBJECTIVES: The study goals were (1) to determine the effect of gender on basal and exercise-induced plasma concentrations of catecholamines and volume-regulatory hormones in patients diagnosed with CHD, New York Heart Association class I and (2) to determine efficacy of the 6-minute walk test as a stimulus for release of these hormones. METHODS: Study participants were 9 women and 9 men with normal left ventricular ejection fraction (>50%) and CHD confirmed by arteriography. Data were collected under resting conditions, and after the 6-minute walk test, in the general clinical research center of a northeastern university medical center. RESULTS: Basal plasma vasopressin (VP) concentration was significantly higher in men than in women (P =. 018). Exercise, for women and men combined, significantly increased atrial natriuretic peptide (P <. 0005), VP (P =. 04), norepinephrine (P <. 0005), and epinephrine (P =. 038) but not plasma renin activity (P =. 09). No further gender differences were detected for basal levels, or for the magnitude of exercise-induced increases, for any of the hormones measured. CONCLUSIONS: The 6-minute walk test is an exercise of sufficient intensity and duration to initiate the release of hormones associated with sympathetic activation and fluid-electrolyte regulation in both women and men with CHD. It appears that a gender difference was detected only for basal VP levels.
AB - BACKGROUND: Women with coronary heart disease (CHD) are more likely than men to develop congestive heart failure (CHF). Dysregulation of sympathetic and volume-regulatory hormones may contribute to the onset of symptomatic CHF. We hypothesized that this hormonal dysregulation develops at an earlier stage of CHD in women than in men. OBJECTIVES: The study goals were (1) to determine the effect of gender on basal and exercise-induced plasma concentrations of catecholamines and volume-regulatory hormones in patients diagnosed with CHD, New York Heart Association class I and (2) to determine efficacy of the 6-minute walk test as a stimulus for release of these hormones. METHODS: Study participants were 9 women and 9 men with normal left ventricular ejection fraction (>50%) and CHD confirmed by arteriography. Data were collected under resting conditions, and after the 6-minute walk test, in the general clinical research center of a northeastern university medical center. RESULTS: Basal plasma vasopressin (VP) concentration was significantly higher in men than in women (P =. 018). Exercise, for women and men combined, significantly increased atrial natriuretic peptide (P <. 0005), VP (P =. 04), norepinephrine (P <. 0005), and epinephrine (P =. 038) but not plasma renin activity (P =. 09). No further gender differences were detected for basal levels, or for the magnitude of exercise-induced increases, for any of the hormones measured. CONCLUSIONS: The 6-minute walk test is an exercise of sufficient intensity and duration to initiate the release of hormones associated with sympathetic activation and fluid-electrolyte regulation in both women and men with CHD. It appears that a gender difference was detected only for basal VP levels.
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U2 - 10.1016/j.hrtlng.2004.08.002
DO - 10.1016/j.hrtlng.2004.08.002
M3 - Article
C2 - 15761458
AN - SCOPUS:14844304280
SN - 0147-9563
VL - 34
SP - 126
EP - 135
JO - Heart and Lung: Journal of Acute and Critical Care
JF - Heart and Lung: Journal of Acute and Critical Care
IS - 2
ER -