Hormonal responses to the 6-minute walk test in women and men with coronary heart disease: A pilot study

Karen J. Radke, Kathleen B. King, Martha L. Blair, Patricia G. Fitzpatrick, Deborah Eldredge

    Research output: Contribution to journalArticle

    6 Citations (Scopus)

    Abstract

    BACKGROUND: Women with coronary heart disease (CHD) are more likely than men to develop congestive heart failure (CHF). Dysregulation of sympathetic and volume-regulatory hormones may contribute to the onset of symptomatic CHF. We hypothesized that this hormonal dysregulation develops at an earlier stage of CHD in women than in men. OBJECTIVES: The study goals were (1) to determine the effect of gender on basal and exercise-induced plasma concentrations of catecholamines and volume-regulatory hormones in patients diagnosed with CHD, New York Heart Association class I and (2) to determine efficacy of the 6-minute walk test as a stimulus for release of these hormones. METHODS: Study participants were 9 women and 9 men with normal left ventricular ejection fraction (>50%) and CHD confirmed by arteriography. Data were collected under resting conditions, and after the 6-minute walk test, in the general clinical research center of a northeastern university medical center. RESULTS: Basal plasma vasopressin (VP) concentration was significantly higher in men than in women (P =. 018). Exercise, for women and men combined, significantly increased atrial natriuretic peptide (P

    Original languageEnglish (US)
    Pages (from-to)126-135
    Number of pages10
    JournalHeart and Lung: Journal of Acute and Critical Care
    Volume34
    Issue number2
    DOIs
    StatePublished - Mar 2005

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    Coronary Disease
    Hormones
    Heart Failure
    Exercise
    Atrial Natriuretic Factor
    Vasopressins
    Stroke Volume
    Catecholamines
    Angiography
    Walk Test
    Research

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine
    • Critical Care and Intensive Care Medicine
    • Pulmonary and Respiratory Medicine

    Cite this

    Hormonal responses to the 6-minute walk test in women and men with coronary heart disease : A pilot study. / Radke, Karen J.; King, Kathleen B.; Blair, Martha L.; Fitzpatrick, Patricia G.; Eldredge, Deborah.

    In: Heart and Lung: Journal of Acute and Critical Care, Vol. 34, No. 2, 03.2005, p. 126-135.

    Research output: Contribution to journalArticle

    Radke, Karen J. ; King, Kathleen B. ; Blair, Martha L. ; Fitzpatrick, Patricia G. ; Eldredge, Deborah. / Hormonal responses to the 6-minute walk test in women and men with coronary heart disease : A pilot study. In: Heart and Lung: Journal of Acute and Critical Care. 2005 ; Vol. 34, No. 2. pp. 126-135.
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