Hormonal basis of variation in oestrous cyclicity in selected strains of mice

D. D. DeLeon, M. B. Zelinski-Wooten, M. S. Barkley

    Research output: Contribution to journalArticle

    20 Scopus citations

    Abstract

    Reproductive hormone secretion and ovarian LH receptor content were studied during the oestrous cycle of mice that differed in fertility after genetic selection. Strain variation in the secretory pattern of progesterone was observed along with differences in the timing and magnitude of prolactin release. Scatchard analysis showed similar affinities of the LH receptor for hCG in strains with increased or decreased reproductive performance, with a single order of binding sites during both pro-oestrus and dioestrus. The number of unoccupied LH receptors during pro-oestrus was greatest in mice with increased reproductive performance. These results provide evidence that trait selection can change gonadotrophin receptor concentration and the dynamics of hormone secretion during the oestrous cycle of the mouse.

    Original languageEnglish (US)
    Pages (from-to)117-126
    Number of pages10
    JournalJournal of Reproduction and Fertility
    Volume89
    Issue number1
    DOIs
    StatePublished - Jan 1 1990

    Keywords

    • LH receptor
    • genotype
    • mouse
    • oestrous cycle
    • progesterone
    • prolactin

    ASJC Scopus subject areas

    • Physiology
    • Embryology
    • Molecular Biology
    • Obstetrics and Gynecology
    • Developmental Biology

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