Hormonal basis of variation in oestrous cyclicity in selected strains of mice

D. D. DeLeon, M. B. Zelinski-Wooten, M. S. Barkley

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Reproductive hormone secretion and ovarian LH receptor content were studied during the oestrous cycle of mice that differed in fertility after genetic selection. Strain variation in the secretory pattern of progesterone was observed along with differences in the timing and magnitude of prolactin release. Scatchard analysis showed similar affinities of the LH receptor for hCG in strains with increased or decreased reproductive performance, with a single order of binding sites during both pro-oestrus and dioestrus. The number of unoccupied LH receptors during pro-oestrus was greatest in mice with increased reproductive performance. These results provide evidence that trait selection can change gonadotrophin receptor concentration and the dynamics of hormone secretion during the oestrous cycle of the mouse.

Original languageEnglish (US)
Pages (from-to)117-126
Number of pages10
JournalJournal of Reproduction and Fertility
Volume89
Issue number1
DOIs
StatePublished - 1990
Externally publishedYes

Keywords

  • LH receptor
  • genotype
  • mouse
  • oestrous cycle
  • progesterone
  • prolactin

ASJC Scopus subject areas

  • Physiology
  • Embryology
  • Molecular Biology
  • Obstetrics and Gynecology
  • Developmental Biology

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