Hormonal basis of variation in oestrous cyclicity in selected strains of mice

D. D. DeLeon, Mary Zelinski, M. S. Barkley

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Reproductive hormone secretion and ovarian LH receptor content were studied during the oestrous cycle of mice that differed in fertility after genetic selection. Strain variation in the secretory pattern of progesterone was observed along with differences in the timing and magnitude of prolactin release. Scatchard analysis showed similar affinities of the LH receptor for hCG in strains with increased or decreased reproductive performance, with a single order of binding sites during both pro-oestrus and dioestrus. The number of unoccupied LH receptors during pro-oestrus was greatest in mice with increased reproductive performance. These results provide evidence that trait selection can change gonadotrophin receptor concentration and the dynamics of hormone secretion during the oestrous cycle of the mouse.

Original languageEnglish (US)
Pages (from-to)117-126
Number of pages10
JournalJournal of Reproduction and Fertility
Volume89
Issue number1
StatePublished - 1990
Externally publishedYes

Fingerprint

LH Receptors
Periodicity
Estrus
Gonadotropin Receptors
Hormones
Diestrus
Genetic Selection
Prolactin
Progesterone
Fertility
Binding Sites

Keywords

  • genotype
  • LH receptor
  • mouse
  • oestrous cycle
  • progesterone
  • prolactin

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Embryology
  • Developmental Biology
  • Molecular Biology
  • Physiology

Cite this

Hormonal basis of variation in oestrous cyclicity in selected strains of mice. / DeLeon, D. D.; Zelinski, Mary; Barkley, M. S.

In: Journal of Reproduction and Fertility, Vol. 89, No. 1, 1990, p. 117-126.

Research output: Contribution to journalArticle

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