Hormonal and metabolic effects and pharmacokinetics of recombinant insulin-like growth factor-I in growth hormone receptor deficiency/Laron syndrome

Mary A. Vaccarello, Frank B. Diamond, Jaime Guevara-Aguirre, Arlan L. Rosenbloom, Paul J. Fielder, Sharron Gargosky, Pinchas Cohen, Kristin Wilson, Ronald (Ron) Rosenfeld

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

Profound growth failure despite elevated GH levels in GH receptor defiency (GHRD) results from reduced insulin-like growth factor-I (IGF-I) synthesis. Recent reports of improved growth velocity in children with GHRD during IGF-I therapy indicate growth-promoting potential in humans. We evaluated the pharmacokinetics and metabolic/hormonal effects of recombinant human IGF-I (40 Mg/kg every 12 h) given sc for 7 days to six adults with GHRD. Hypoglycemia (

Original languageEnglish (US)
Pages (from-to)273-280
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume77
Issue number1
StatePublished - Jul 1993
Externally publishedYes

Fingerprint

Laron Syndrome
Somatotropin Receptors
Pharmacokinetics
Insulin-Like Growth Factor I
Growth
Hypoglycemia
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Vaccarello, M. A., Diamond, F. B., Guevara-Aguirre, J., Rosenbloom, A. L., Fielder, P. J., Gargosky, S., ... Rosenfeld, R. R. (1993). Hormonal and metabolic effects and pharmacokinetics of recombinant insulin-like growth factor-I in growth hormone receptor deficiency/Laron syndrome. Journal of Clinical Endocrinology and Metabolism, 77(1), 273-280.

Hormonal and metabolic effects and pharmacokinetics of recombinant insulin-like growth factor-I in growth hormone receptor deficiency/Laron syndrome. / Vaccarello, Mary A.; Diamond, Frank B.; Guevara-Aguirre, Jaime; Rosenbloom, Arlan L.; Fielder, Paul J.; Gargosky, Sharron; Cohen, Pinchas; Wilson, Kristin; Rosenfeld, Ronald (Ron).

In: Journal of Clinical Endocrinology and Metabolism, Vol. 77, No. 1, 07.1993, p. 273-280.

Research output: Contribution to journalArticle

Vaccarello, MA, Diamond, FB, Guevara-Aguirre, J, Rosenbloom, AL, Fielder, PJ, Gargosky, S, Cohen, P, Wilson, K & Rosenfeld, RR 1993, 'Hormonal and metabolic effects and pharmacokinetics of recombinant insulin-like growth factor-I in growth hormone receptor deficiency/Laron syndrome', Journal of Clinical Endocrinology and Metabolism, vol. 77, no. 1, pp. 273-280.
Vaccarello, Mary A. ; Diamond, Frank B. ; Guevara-Aguirre, Jaime ; Rosenbloom, Arlan L. ; Fielder, Paul J. ; Gargosky, Sharron ; Cohen, Pinchas ; Wilson, Kristin ; Rosenfeld, Ronald (Ron). / Hormonal and metabolic effects and pharmacokinetics of recombinant insulin-like growth factor-I in growth hormone receptor deficiency/Laron syndrome. In: Journal of Clinical Endocrinology and Metabolism. 1993 ; Vol. 77, No. 1. pp. 273-280.
@article{52050187e1d34455901cac89b7e43ebd,
title = "Hormonal and metabolic effects and pharmacokinetics of recombinant insulin-like growth factor-I in growth hormone receptor deficiency/Laron syndrome",
abstract = "Profound growth failure despite elevated GH levels in GH receptor defiency (GHRD) results from reduced insulin-like growth factor-I (IGF-I) synthesis. Recent reports of improved growth velocity in children with GHRD during IGF-I therapy indicate growth-promoting potential in humans. We evaluated the pharmacokinetics and metabolic/hormonal effects of recombinant human IGF-I (40 Mg/kg every 12 h) given sc for 7 days to six adults with GHRD. Hypoglycemia (",
author = "Vaccarello, {Mary A.} and Diamond, {Frank B.} and Jaime Guevara-Aguirre and Rosenbloom, {Arlan L.} and Fielder, {Paul J.} and Sharron Gargosky and Pinchas Cohen and Kristin Wilson and Rosenfeld, {Ronald (Ron)}",
year = "1993",
month = "7",
language = "English (US)",
volume = "77",
pages = "273--280",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "1",

}

TY - JOUR

T1 - Hormonal and metabolic effects and pharmacokinetics of recombinant insulin-like growth factor-I in growth hormone receptor deficiency/Laron syndrome

AU - Vaccarello, Mary A.

AU - Diamond, Frank B.

AU - Guevara-Aguirre, Jaime

AU - Rosenbloom, Arlan L.

AU - Fielder, Paul J.

AU - Gargosky, Sharron

AU - Cohen, Pinchas

AU - Wilson, Kristin

AU - Rosenfeld, Ronald (Ron)

PY - 1993/7

Y1 - 1993/7

N2 - Profound growth failure despite elevated GH levels in GH receptor defiency (GHRD) results from reduced insulin-like growth factor-I (IGF-I) synthesis. Recent reports of improved growth velocity in children with GHRD during IGF-I therapy indicate growth-promoting potential in humans. We evaluated the pharmacokinetics and metabolic/hormonal effects of recombinant human IGF-I (40 Mg/kg every 12 h) given sc for 7 days to six adults with GHRD. Hypoglycemia (

AB - Profound growth failure despite elevated GH levels in GH receptor defiency (GHRD) results from reduced insulin-like growth factor-I (IGF-I) synthesis. Recent reports of improved growth velocity in children with GHRD during IGF-I therapy indicate growth-promoting potential in humans. We evaluated the pharmacokinetics and metabolic/hormonal effects of recombinant human IGF-I (40 Mg/kg every 12 h) given sc for 7 days to six adults with GHRD. Hypoglycemia (

UR - http://www.scopus.com/inward/record.url?scp=0027272980&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027272980&partnerID=8YFLogxK

M3 - Article

C2 - 7686916

AN - SCOPUS:0027272980

VL - 77

SP - 273

EP - 280

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 1

ER -